Long-term cumulative physical activity associated with less cognitive decline: Evidence from a 16-year cohort study.

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The Journal of Prevention of Alzheimer's Disease Pub Date : 2025-04-30 DOI:10.1016/j.tjpad.2025.100194

Suhang Song, Meng Hsuan Sung, Diana Diaz, Zhuofan Lin, Allan D Tate, Zhuo Chen, Janani Rajbhandari-Thapa, Grace Bagwell Adams, M Mahmud Khan, Ye Shen, Lisa M Renzi-Hammond, Yinzi Jin

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引用次数: 0

Abstract

Introduction: Physical activity (PA) has been reported to delay cognitive decline. However, the role of long-term, cumulative PA (cPA) in cognitive decline remains unclear.

Methods: This longitudinal study obtained data from Health and Retirement Study, 2004-2020. Global cognition was operationalized as the sum of memory and executive function scores on a battery of cognitive tests. cPA was operationalized as the area under the curve of the metabolic equivalent of tasks (MET) adjusted PA. Generalized linear mixed models were fitted to examine the associations between cPA and cognitive change.

Results: This study included 13,450 cognitively healthy participants, with a mean follow-up duration of 11.06 (SD=4.91) years. Higher cPA was associated with delayed declines in global cognition (p<.001), memory (p<.001) and executive function (p<.001), and such protective benefits grew over the 16-year study period. Longer PA engagement was associated with progressively delayed cognitive decline.

Conclusion: PA engagement over long timeframes may better maintain cognitive performance.

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长期累积体力活动与认知能力下降相关：来自16年队列研究的证据。

体育活动（PA）已被报道可以延缓认知能力下降。然而，长期累积PA （cPA）在认知能力下降中的作用尚不清楚。方法：本纵向研究获得2004-2020年健康与退休研究的数据。在一系列认知测试中，整体认知被操作化为记忆和执行功能得分的总和。cPA被操作为代谢任务当量（MET）调整PA曲线下的面积。采用广义线性混合模型检验cPA与认知变化之间的关系。结果：本研究纳入13450名认知健康的参与者，平均随访时间为11.06年（SD=4.91）年。较高的cPA与整体认知的延迟下降有关(结论：长期的PA参与可能更好地维持认知表现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health

CiteScore

9.20

自引率

0.00%

发文量

期刊介绍： The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.