KRASG12C/mTORC1 inhibition: a powerful duo in NSCLC therapeutics.
IF 13.9
1区 医学
Q1 PHARMACOLOGY & PHARMACY
Trends in pharmacological sciences
Pub Date : 2025-05-01
Epub Date: 2025-04-14
DOI:10.1016/j.tips.2025.03.009
引用次数: 0
Abstract
In a recent report in Nature Communications, Kitai et al. designed a combinational treatment based on targeting the active-state KRASG12C-mutant variant that characterizes a substantial subset of non-small-cell lung cancer (NSCLC) cases. The authors highlighted that dual targeting with KRASG12C (ON) and mammalian target of rapamycin (mTOR) complex (mTORC)-1-selective inhibition potentially provides a new strategy to overcome drug resistance.
KRASG12C/mTORC1抑制：非小细胞肺癌治疗中的一个强大的组合。
在Nature Communications最近的一篇报道中，Kitai等人设计了一种基于靶向活性状态krasg12c突变变体的联合治疗方法，该变体是非小细胞肺癌（NSCLC）病例的一大特征。作者强调，KRASG12C （ON）和哺乳动物雷帕霉素（mTOR）复合物(mTORC)-1选择性抑制的双重靶向可能提供一种克服耐药的新策略。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
CiteScore
23.90
自引率
0.70%
发文量
132
审稿时长
6-12 weeks
期刊介绍：
Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research.
The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics.
Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles.
Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.
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