Evolving Therapeutics for Resectable Esophageal Adenocarcinoma.

IF 14.8 2区 医学 Q1 ONCOLOGY
Kelsey A Klute, Manish A Shah
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引用次数: 0

Abstract

Surgical resection remains the backbone of curative treatment for localized esophageal adenocarcinoma. However, resection alone carries a significant risk of recurrence and is no longer considered an acceptable approach for patients with locally advanced disease. Strategies incorporating perioperative chemotherapy, neoadjuvant chemoradiotherapy, and adjuvant immune checkpoint blockade have significantly improved survival. However, despite these advances, approximately half of all patients with locally advanced disease will experience recurrence and ultimately succumb to their disease. To overcome this innate resistance to cytotoxic therapy, novel strategies are being developed. This review discusses both evidence-based and emerging perioperative approaches and explores potential risk-adapted strategies to individualize perioperative therapy.

可切除食管腺癌的新疗法。
手术切除仍然是根治性治疗局限性食管腺癌的支柱。然而,单独切除具有显著的复发风险,不再被认为是局部晚期疾病患者可接受的方法。围手术期化疗、新辅助放化疗和辅助免疫检查点阻断的策略显著提高了生存率。然而,尽管取得了这些进展,但大约一半的局部晚期疾病患者将经历复发并最终死于疾病。为了克服这种对细胞毒性治疗的先天抗性,新的策略正在开发中。这篇综述讨论了循证和新兴围手术期方法,并探讨了潜在的风险适应策略,以个性化围手术期治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
20.20
自引率
0.00%
发文量
388
审稿时长
4-8 weeks
期刊介绍: JNCCN—Journal of the National Comprehensive Cancer Network is a peer-reviewed medical journal read by over 25,000 oncologists and cancer care professionals nationwide. This indexed publication delivers the latest insights into best clinical practices, oncology health services research, and translational medicine. Notably, JNCCN provides updates on the NCCN Clinical Practice Guidelines in Oncology® (NCCN Guidelines®), review articles elaborating on guideline recommendations, health services research, and case reports that spotlight molecular insights in patient care. Guided by its vision, JNCCN seeks to advance the mission of NCCN by serving as the primary resource for information on NCCN Guidelines®, innovation in translational medicine, and scientific studies related to oncology health services research. This encompasses quality care and value, bioethics, comparative and cost effectiveness, public policy, and interventional research on supportive care and survivorship. JNCCN boasts indexing by prominent databases such as MEDLINE/PubMed, Chemical Abstracts, Embase, EmCare, and Scopus, reinforcing its standing as a reputable source for comprehensive information in the field of oncology.
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