Associations between the Platelet Lymphocyte Ratio and Albumin with Plaque Calcification in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study.

IF 1.9 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Reviews in cardiovascular medicine Pub Date : 2025-04-27 eCollection Date: 2025-04-01 DOI:10.31083/RCM28167

Kexin Song, Wenjing Yao, Haihao Yan, Yan Zhang, Yanhong Li, Tianxing Li, Qian Yang, Feifei Zhang, Yi Dang

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引用次数: 0

Abstract

Background: Coronary artery calcification (CAC) is a robust independent predictor of cardiovascular events. Therefore, it is essential to elucidate the factors that influence CAC progression to enhance the outcomes of patients diagnosed with acute coronary syndrome (ACS). This study aimed to investigate the relationship between prevalent laboratory parameters and the calcification of coronary artery plaques in patients diagnosed with ACS by applying optical coherence tomography (OCT).

Methods: This single-center, cross-sectional study retrospectively evaluated patients with ACS who underwent percutaneous coronary intervention and OCT examinations at the Hebei General Hospital. Baseline data, laboratory parameters, and OCT imaging were analyzed. Comprehensive statistical analyses were conducted to elucidate the relationship between prevalent laboratory parameters and coronary artery plaque calcification.

Results: In this study involving 130 patients, the platelet to lymphocyte ratio (PLR) demonstrated a significant positive correlation with coronary artery plaque calcification (r_s = 0.373, p < 0.001), whereas albumin exhibited a significant negative correlation (r_s = -0.585, p < 0.001). Both the PLR (odds ratios (OR) 1.011, 95% CI 1.002-1.019, p = 0.014) and albumin levels (OR 0.642, 95% CI 0.539-0.764, p < 0.001) emerged as significant independent predictors of plaque calcification. Receiver operating characteristic curve analysis identified a cutoff point for albumin at <40.65, yielding a sensitivity of 75.8% and a specificity of 77.9%, Comparatively, a PLR >145.04 demonstrated a sensitivity of 61.3% and a specificity of 76.5% for predicting plaque calcification.

Conclusions: Albumin and the PLR were significantly associated with plaque calcification in patients with ACS, serving as independent predictors of coronary artery plaque calcification. These parameters may significantly contribute to risk stratification and the future development of preventive strategies to mitigate adverse cardiovascular events.

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急性冠脉综合征患者血小板淋巴细胞比例和白蛋白与斑块钙化之间的关系：光学相干断层扫描研究

背景：冠状动脉钙化（CAC）是心血管事件的可靠独立预测因子。因此，有必要阐明影响CAC进展的因素，以提高诊断为急性冠脉综合征（ACS）患者的预后。本研究旨在通过光学相干断层扫描（OCT）探讨ACS患者常用实验室参数与冠状动脉斑块钙化的关系。方法：本单中心横断面研究回顾性评价在河北总医院行经皮冠状动脉介入治疗和OCT检查的ACS患者。分析基线数据、实验室参数和OCT成像。通过全面的统计分析，阐明了流行的实验室参数与冠状动脉斑块钙化的关系。结果：本研究共纳入130例患者，血小板与淋巴细胞比值（PLR）与冠状动脉斑块钙化呈显著正相关（rs = 0.373, p < 0.001），白蛋白与冠状动脉斑块钙化呈显著负相关（rs = -0.585, p < 0.001）。PLR（比值比（OR） 1.011, 95% CI 1.002-1.019, p = 0.014）和白蛋白水平（OR 0.642, 95% CI 0.539-0.764, p < 0.001）均成为斑块钙化的重要独立预测因子。受试者工作特征曲线分析确定白蛋白的临界值为145.04，预测斑块钙化的敏感性为61.3%，特异性为76.5%。结论：白蛋白和PLR与ACS患者斑块钙化有显著相关性，可作为冠脉斑块钙化的独立预测因子。这些参数可能有助于风险分层和未来预防策略的发展，以减轻不良心血管事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews in cardiovascular medicine 医学-心血管系统

CiteScore

2.70

自引率

3.70%

发文量

377

审稿时长

1 months

期刊介绍： RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.