Multifocal cancer is associated with better survival than solitary cancer in non-Hispanic White patients with thyroid carcinoma.

IF 1.5 3区医学 Q3 SURGERY

Gland surgery Pub Date : 2025-03-31 Epub Date: 2025-03-26 DOI:10.21037/gs-2024-523

Yu Li, Da Huang, Jian Ding, Wei Mao, Dan Luo, Yuan Zhou, Baoxin Wang, Haiting Liang, Zhiqiang Wang, Pin Dong

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引用次数: 0

Abstract

Background: Multifocal carcinoma is commonly reported in thyroid cancer. However, its impact on cancer survival is unclear. This study aims to evaluate whether multifocal disease is associated with better thyroid cancer outcomes in different ethnicities.

Methods: Cancer registration data in the US from 2000 to 2016 were obtained via the Surveillance, Epidemiology, and End Results (SEER) 18 Registries database. Patients diagnosed with thyroid carcinoma and without other malignancies were enrolled. Univariable and multivariable Cox regressions were applied to evaluate the association of multifocal disease with cancer-specific survival (CSS) and overall survival (OS). Multivariable analyses were performed after adjusting for age, gender, stage, and treatment.

Results: A total of 82,217, 8,551, 13,445, and 19,558 non-Hispanic White (NHW), non-Hispanic African American (AA), non-Hispanic Asian or Pacific Islander (AP), and Hispanic White (HW) patients were enrolled in this study, respectively. Univariable analysis suggested that multifocal carcinoma would have significant better CSS [hazard ratio (HR) =0.89, 95% confidence interval (CI): 0.77-1.02, P=0.09; adjusted HR =0.67, 95% CI: 0.53-0.85, P<0.001] and OS (HR =0.83, 95% CI: 0.77-0.90, P<0.001; adjusted HR =0.76, 95% CI: 0.65-0.87, P<0.001) than solitary disease in NHW.

Conclusions: Multifocal thyroid carcinoma is associated with better CSS and OS than solitary cancer in NHW patients.

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非西班牙裔白人甲状腺癌患者的多灶性癌比单发性癌生存率更高。

背景：多灶性甲状腺癌是常见的甲状腺癌。然而，它对癌症存活率的影响尚不清楚。本研究旨在评估不同种族的多灶性疾病是否与更好的甲状腺癌预后相关。方法：通过监测、流行病学和最终结果（SEER） 18登记处数据库获得2000年至2016年美国癌症登记数据。诊断为甲状腺癌且无其他恶性肿瘤的患者被纳入研究。应用单变量和多变量Cox回归评估多灶性疾病与癌症特异性生存（CSS）和总生存（OS）的关系。在调整年龄、性别、分期和治疗后进行多变量分析。结果：共有82,217例、8,551例、13,445例和19,558例非西班牙裔白人（NHW）、非西班牙裔非洲裔美国人（AA）、非西班牙裔亚洲人或太平洋岛民（AP）和西班牙裔白人（HW）患者入组本研究。单因素分析显示，多灶性癌有明显更好的CSS[风险比(HR) =0.89, 95%可信区间（CI）： 0.77 ~ 1.02， P=0.09；调整后HR =0.67, 95% CI: 0.53-0.85，结论：NHW患者多灶性甲状腺癌比单发性甲状腺癌具有更好的CSS和OS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gland surgery Medicine-Surgery

CiteScore

3.60

自引率

0.00%

发文量

113

期刊介绍： Gland Surgery (Gland Surg; GS, Print ISSN 2227-684X; Online ISSN 2227-8575) being indexed by PubMed/PubMed Central, is an open access, peer-review journal launched at May of 2012, published bio-monthly since February 2015.