A Case Report and Literature Review of ANCA-Associated Vasculitis and Lupus Nephritis Overlap: Lessons in Management.

Glomerular diseases Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI:10.1159/000543014

Gabriel Dardik, Anna Krieger, Maya K Rao, Michael B Stokes, Benjamin Wooden, Andrew S Bomback

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Abstract

Introduction: ANCA-associated vasculitis (AAV) and lupus nephritis (LN) are distinct disease processes that both cause a nephritic picture with acute kidney injury but have different pathophysiologies and thus different treatment strategies. They also have different characteristic phenotypes on kidney biopsy. Rarely, the two processes can coincide in one patient, known as AAV-LN overlap syndrome.

Case presentation: We present the case of a 78-year-old woman who presented with a rapidly progressive kidney injury and nephritic syndrome. Initial workup suggested AAV, but further serologies and ultimately a kidney biopsy demonstrated an overlap of both AAV and LN. Management was changed after discovery of this rare syndrome.

Conclusion: A low threshold for ordering serologies and early kidney biopsy are warranted in both AAV and LN as AAV-LN overlap has a unique management strategy that may respond to tailored treatment.

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anca相关性血管炎与狼疮性肾炎重叠1例报告及文献回顾：治疗经验。

anca相关性血管炎（AAV）和狼疮性肾炎（LN）是不同的疾病过程，两者都导致急性肾损伤的肾病症状，但具有不同的病理生理学，因此具有不同的治疗策略。它们在肾活检中也有不同的特征性表型。罕见的是，这两个过程可以同时发生在一个病人身上，称为AAV-LN重叠综合征。病例介绍：我们提出的情况下，78岁的妇女谁提出了一个迅速进展的肾损伤和肾病综合征。最初的检查提示AAV，但进一步的血清学和最终的肾活检显示AAV和LN重叠。在发现这种罕见的综合征后，治疗方法发生了变化。结论：AAV-LN重叠具有独特的管理策略，可能对量身定制的治疗有反应，因此AAV和LN的血清学和早期肾活检的低阈值是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Glomerular diseases

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