Tumor mutational burden status and clinical characteristics of invasive lobular carcinoma of the breast.

IF 2.9 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Cancer Pub Date : 2025-07-01 Epub Date: 2025-05-02 DOI:10.1007/s12282-025-01706-6

Yuko Takano, Kazuyuki Mizuno, Madoka Iwase, Sachi Morita, Nao Torii, Toyone Kikumori, Yuichi Ando

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引用次数: 0

Abstract

Background: High tumor mutational burden (TMB-H) is an established biomarker for a favorable response to immune checkpoint inhibitors. However, tumor mutational burden (TMB) in invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) has not been sufficiently investigated.

Methods: We collected data of patients with ILC or IDC from the Center for Cancer Genomics and Advanced Therapeutics database between June 2019 and August 2023. Furthermore, we examined the clinicopathological factors and TMB status.

Results: Patients with ILC (n = 170) had a median TMB score of 4.00 mut/Mb (interquartile range, 2.00-7.14 mut/Mb), whereas those with IDC (n = 2598) had a score of 3.90 mut/Mb (2.00-6.00 mut/Mb). TMB-H was more common in patients with ILC than in those with IDC (18.2% vs. 10.1%, P < 0.001), particularly in the ER+ /HER2- subtype. Multivariate analysis revealed that the pathological diagnosis of ILC (P = 0.006), tissue samples collected from metastatic sites (P < 0.001), and older age (50 years, P < 0.001) were independent factors for TMB-H.

Conclusions: Patients with ILC were more likely to have TMB-H than those with IDC. The findings of this study would be invaluable in selecting treatment strategies for patients with ILC.

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乳腺浸润性小叶癌的肿瘤突变负荷状况及临床特点。

背景：高肿瘤突变负荷（TMB-H）是对免疫检查点抑制剂有利反应的既定生物标志物。然而，浸润性导管癌（IDC）和浸润性小叶癌（ILC）的肿瘤突变负荷（TMB）尚未得到充分的研究。方法：我们从2019年6月至2023年8月癌症基因组学和高级治疗中心数据库中收集ILC或IDC患者的数据。此外，我们还检查了临床病理因素和TMB状态。结果：ILC患者（n = 170）的中位TMB评分为4.00 mut/Mb（四分位数范围为2.00-7.14 mut/Mb），而IDC患者（n = 2598）的中位TMB评分为3.90 mut/Mb （2.00-6.00 mut/Mb）。TMB-H在ILC患者中比在IDC患者中更常见（18.2%比10.1%）。结论：ILC患者比IDC患者更容易发生TMB-H。本研究结果将对ILC患者的治疗策略选择具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Cancer ONCOLOGY-OBSTETRICS & GYNECOLOGY

CiteScore

6.70

自引率

2.50%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Breast Cancer, the official journal of the Japanese Breast Cancer Society, publishes articles that contribute to progress in the field, in basic or translational research and also in clinical research, seeking to develop a new focus and new perspectives for all who are concerned with breast cancer. The journal welcomes all original articles describing clinical and epidemiological studies and laboratory investigations regarding breast cancer and related diseases. The journal will consider five types of articles: editorials, review articles, original articles, case reports, and rapid communications. Although editorials and review articles will principally be solicited by the editors, they can also be submitted for peer review, as in the case of original articles. The journal provides the best of up-to-date information on breast cancer, presenting readers with high-impact, original work focusing on pivotal issues.