Asymptomatic Wilson's Disease Diagnosed during the Course of Ulcerative Colitis: A Case Report and Review.

Q2 Medicine

Inflammatory Intestinal Diseases Pub Date : 2025-03-13 eCollection Date: 2025-01-01 DOI:10.1159/000545142

Megumi Kinjo, Shintaro Sagami, Akira Nogami, Kanade Serizawa, Shunsuke Shibui, Satoko Umeda, Kunio Asonuma, Hidetsugu Saito, Masaru Nakano, Toshifumi Hibi, Taku Kobayashi

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Abstract

Introduction: While previous reports have suggested an association between Wilson's disease (WD) and ulcerative colitis (UC), we present the first case of asymptomatic WD diagnosed during the treatment course of UC.

Case presentation: A 14-year-old male receiving treatment for UC developed elevated liver enzymes without any related symptoms. After ruling out drug-induced liver toxicity and other possible causes of hepatitis, further investigation was initiated due to his sister's subsequent diagnosis of WD. Tests revealed low serum ceruloplasmin and ATP7B gene variants, confirming WD. Following zinc therapy, liver enzymes have been normalized, and his previously refractory UC became under control.

Conclusion: This case raises important questions about potential pathophysiological interactions between the two diseases.

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溃疡性结肠炎期间诊断无症状威尔逊氏病1例报告及回顾。

导语：虽然以前的报道表明威尔逊氏病（WD）和溃疡性结肠炎（UC）之间存在关联，但我们提出了第一例在UC治疗过程中诊断出无症状WD的病例。病例介绍：一名接受UC治疗的14岁男性在没有任何相关症状的情况下出现肝酶升高。在排除了药物性肝毒性和其他可能的肝炎原因后，由于其姐姐随后被诊断为WD，我们开始了进一步的调查。试验显示血清铜蓝蛋白和ATP7B基因变异低，证实WD。锌治疗后，肝酶恢复正常，既往难治性UC得到控制。结论：本病例提出了两种疾病之间潜在的病理生理相互作用的重要问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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