Podocyte Infolding Glomerulopathy: Case Series From a Tertiary Hospital in India.

Abstract

Podocyte infolding glomerulopathy is a rare pathological entity characterised by invagination of the podocyte cell membrane into the glomerular basement membrane with presence of microspheres and/or microtubules on electron microscopy. Without an ultrastructure study, it is often confused with and misdiagnosed as membranous nephropathy. The pathogenesis of this disease remains unclear and the majority of cases show association with connective tissue disorders. There is an ongoing debate on whether it represents a distinct disease entity or merely an unusual renal pathological finding of coexisting disease. Till date, only a single case report has been reported from India. We present a series of 4 cases from India along with a review of literature. This case series aims to provide some insights highlighting the clinical, light microscopic, and diagnostic electron microscopic aspects of this uncommon entity.