Does the High Renal Resistive Index Reveal an Increased Risk of Acute Kidney Injury? A Protocol for Systematic Review.

Q4 Medicine
Giuseppe Cuttone, Giulio Geraci, Luigi La Via, Nicola Sinatra, Maria Rita Stancanelli, Vincenzo Calabrese
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引用次数: 0

Abstract

Introduction. Acute Kidney Injury (AKI) is a serious complication in critically ill patients associated with significant morbidity and mortality. Early detection and risk stratification remain challenging, particularly in complex conditions such as septic shock where hemodynamic alterations complicate the clinical picture. Renal Resistive Index (RRI), measured through Doppler ultrasonography, has emerged as a promising non-invasive tool for assessing renal hemodynamics and microcirculatory changes. While various studies have investigated the relationship between RRI and AKI, there has not been a comprehensive systematic evaluation of RRI's utility in predicting and assessing AKI in critical care settings. Objective. The main aim is to evaluate the difference in RRI between patients who manifested AKI and patients who did not manifest AKI. Furthermore, the risk of AKI occurrence related to RRI will be computed. Methods. We will perform systematic research in PubMed and Scopus according to the PRISMA Guidelines. We will screen observational studies, with both retrospective and prospective designs on critically ill patients, without sex or age restriction. Expected results. This systematic review is expected to provide a comprehensive and extensive evaluation of the relationship between RRI and AKI. It will be based on observational studies, as RRI is a risk factor not subject to control by the investigator. In addition to assessing the association between RRI and AKI, the study also aims to highlight potential gaps in current knowledge and suggest directions for future research. Conclusions. The present systematic review protocol will include all existing evidence from published articles evaluating the RRI values in patients manifesting or not AKI.

高肾阻力指数是否表明急性肾损伤的风险增加?系统评价方案。
介绍。急性肾损伤(AKI)是危重患者的一种严重并发症,具有显著的发病率和死亡率。早期发现和风险分层仍然具有挑战性,特别是在感染性休克等复杂情况下,血流动力学改变使临床表现复杂化。肾阻力指数(RRI),通过多普勒超声测量,已成为评估肾脏血流动力学和微循环变化的有前途的非侵入性工具。虽然各种研究已经调查了RRI和AKI之间的关系,但尚未对RRI在预测和评估重症监护环境中AKI的效用进行全面系统的评估。目标。主要目的是评估表现为AKI的患者和未表现为AKI的患者之间RRI的差异。此外,将计算与RRI相关的AKI发生的风险。方法。我们将根据PRISMA指南在PubMed和Scopus中进行系统研究。我们将筛选观察性研究,对危重患者进行回顾性和前瞻性设计,没有性别或年龄限制。预期的结果。本系统综述有望对RRI和AKI之间的关系提供全面和广泛的评价。它将基于观察性研究,因为RRI是一种不受研究者控制的风险因素。除了评估RRI和AKI之间的关系外,该研究还旨在强调当前知识的潜在差距,并为未来的研究提出方向。结论。目前的系统评价方案将包括来自已发表文章的所有现有证据,这些文章评估了表现为AKI或不表现为AKI的患者的RRI值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.70
自引率
0.00%
发文量
62
期刊介绍: Il Giornale Italiano di Nefrologia (GIN) è la rivista di educazione continua della Società Italiana di Nefrologia SIN ed è pubblicato bimestralmente. E" il più autorevole organo di informazione nefrologia disponibile a livello nazionale. Il giornale Italiano di Nefrologia offre la più aggiornata informazione medico-scientifica rivolta al nefrologo sotto forma di rassegne, casi clinici e articoli finalizzati all’Educazione Continua in Medicina, oltre ai notiziari ed agli atti dei congressi di questa prestigiosa Società Scientifica
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