Causal associations between atrial fibrillation and esophageal cancer: a two-sample Mendelian randomization study.

IF 1.5 4区医学 Q4 ONCOLOGY

Translational cancer research Pub Date : 2025-03-30 Epub Date: 2025-03-10 DOI:10.21037/tcr-24-2107

Jinsong Lei, Longjun Yang, Gongming Wang, Qianwen Liu, Guangran Guo

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引用次数: 0

Abstract

Background: Previous studies indicated that atrial fibrillation (AF) patients had a significantly higher esophageal cancer (EC) risk. However, influencing by confounding factors, the causal effect is uncertain. In this study, we aimed to validate the causal relationship between AF and EC by Mendelian randomization (MR) analysis.

Methods: An observational analysis was conducted using the data from the National Health and Nutrition Examination Survey (NHANES) and UK Biobank. Then a two-sample MR method was employed to assess the causal effect of AF on EC. The exposure of AF was collected from publicly available genome-wide association studies (GWASs). Meanwhile, the EC outcome data were derived from the UK Biobank and the FinnGen consortium. A set of 108 single-nucleotide polymorphisms (SNPs) served as instrumental variables (IVs). The effect estimates were calculated using the inverse variance weighted (IVW) method.

Results: Genetically predicted AF was associated with an increased risk of EC [odds ratio (OR), 1.73; 95% confidence interval (CI): 1.01-1.73; P=0.04]. The similar results could be found by sensitivity analyses and no any evidence of horizontal pleiotropy was observed.

Conclusions: This two-sample MR analysis suggested that AF was causally associated with an increased risk of EC.

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心房颤动和食管癌之间的因果关系：一项双样本孟德尔随机化研究。

背景：既往研究表明，房颤（AF）患者发生食管癌（EC）的风险显著增高。但由于混杂因素的影响，其因果关系是不确定的。在这项研究中，我们旨在通过孟德尔随机化（MR）分析验证AF和EC之间的因果关系。方法：采用国家健康与营养检查调查（NHANES）和英国生物银行的数据进行观察性分析。然后采用双样本MR方法评估AF对EC的因果关系。房颤暴露收集自可公开获得的全基因组关联研究（GWASs）。同时，EC结果数据来自英国生物银行和FinnGen联盟。108个单核苷酸多态性（snp）作为工具变量（iv）。效应估计采用逆方差加权（IVW）法计算。结果：基因预测的房颤与EC风险增加相关[优势比（OR）， 1.73；95%置信区间（CI）： 1.01-1.73；P = 0.04)。敏感性分析也发现了类似的结果，没有发现水平多效性的证据。结论：这两个样本的MR分析表明AF与EC风险增加有因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational cancer research ONCOLOGY-

CiteScore

2.10

自引率

0.00%

发文量

252

期刊介绍： Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.