Comparative survival analysis of stage T1-T2N0M0 lung squamous cell carcinoma and adenocarcinoma using SEER data, and nomogram analysis for early-stage lung squamous cell carcinoma.

IF 1.5 4区 医学 Q4 ONCOLOGY
Translational cancer research Pub Date : 2025-03-30 Epub Date: 2025-03-27 DOI:10.21037/tcr-24-1602
Chang Liu, Cheng Fang, Dan Shen
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引用次数: 0

Abstract

Background: Lung cancer is one of the most common malignant tumors worldwide. It is of great significance to conduct in-depth research on early lung cancer with a better prognosis. This study aimed to use the Surveillance, Epidemiology, and End Results (SEER) database to compare the clinicopathological characteristics and survival between early squamous cell carcinoma (SQCC) and adenocarcinoma (AC) under the same treatment model, and develop a nomogram for early lung SQCC.

Methods: This study examined 40,325 cases of stage T1-T2N0M0 lung SQCC and AC from 2004 to 2019. Propensity score matching (PSM) was used to reduce bias. Kaplan-Meier curves and Cox proportional hazards models were used for assessing lung cancer-specific survival (LCSS) and overall survival (OS) under various treatments. A nomogram for early-stage SQCC was constructed and validated using the concordance index (C-index), calibration curves, and decision curve analysis (DCA).

Results: In patients with T1-T2N0M0 non-small cell lung cancer (NSCLC), when only radiotherapy was performed, the LCSS of patients in the SQCC group was worse than that of the AC group [hazard ratio (HR) =1.20, 95% confidence interval (CI): 1.079-1.336, P<0.001], and same for 3-year LCSS (55.9% vs. 62.7%) and the 5-year LCSS (43.6% vs. 47.8%). The OS of patients in the SQCC group was worse than the AC group (HR =1.32, 95% CI: 1.215-1.429, P<0.001). When only surgical treatment was performed, no statistically significant difference was found in the LCSS between the two groups (HR =1.03, 95% CI: 0.965-1.092, P=0.41). The OS of patients in the SQCC group was worse than the AC group (HR =1.25, 95% CI: 1.200-1.309, P<0.001). Additionally, a nomogram was created to predict survival rates for early-stage lung SQCC patients.

Conclusions: The prognosis of patients with T1-T2N0M0 lung SQCC is worse than that of AC patients. Individualized treatment is recommended in the early stages.

采用SEER数据对T1-T2N0M0期肺鳞状细胞癌与腺癌的生存期进行比较分析,并对早期肺鳞状细胞癌进行nomogram分析。
背景:肺癌是世界范围内最常见的恶性肿瘤之一。对预后较好的早期肺癌进行深入研究具有重要意义。本研究旨在利用监测、流行病学和最终结果(SEER)数据库,比较相同治疗模式下早期鳞状细胞癌(SQCC)和腺癌(AC)的临床病理特征和生存率,并建立早期肺部SQCC的nomogram。方法:本研究对2004 - 2019年40325例T1-T2N0M0期肺SQCC和AC进行了分析。倾向评分匹配(PSM)用于减少偏倚。Kaplan-Meier曲线和Cox比例风险模型用于评估不同治疗下的肺癌特异性生存期(LCSS)和总生存期(OS)。利用一致性指数(C-index)、校准曲线和决策曲线分析(DCA)构建了早期SQCC的nomogram,并对其进行了验证。结果:在T1-T2N0M0非小细胞肺癌(NSCLC)患者中,仅行放疗时,SQCC组患者的LCSS差于AC组[危险比(HR) =1.20, 95%可信区间(CI): 1.079 ~ 1.336,概率比为62.7%]和5年LCSS(43.6%比47.8%)。SQCC组患者的OS较AC组差(HR =1.32, 95% CI: 1.215 ~ 1.429)。结论:T1-T2N0M0肺SQCC患者预后较AC组差。建议在早期阶段进行个体化治疗。
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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
252
期刊介绍: Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.
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