Effectiveness of platelet-rich plasma for treating temporomandibular joint disorders: a systematic review and meta-analysis of randomized controlled trials.
Jui-Hsu Tsai, Ka-Wai Tam, Jheng-Dao Yang, Tzu-Herng Hsu
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引用次数: 0
Abstract
Objective: To investigate the therapeutic effects of platelet-rich plasma (PRP) injection on pain and mandibular movement in patients with temporomandibular joint disorder (TMJD).
Design: Systematic review and meta-analysis of prospective controlled trials. A literature search was conducted in PubMed, Embase, and the Cochrane Library to identify relevant studies published before August 31, 2024.
Setting: Not applicable (systematic review and meta-analysis).
Participants: Patients diagnosed with temporomandibular joint disorder included in the eligible studies.
Intervention(s) or exposure(s): PRP injection compared with arthrocentesis, hyaluronic acid, or corticosteroids.
Main outcome(s) and measure(s): Pain intensity and maximal mandibular opening (MMO) were the primary outcomes. Study quality was assessed using the Cochrane Risk of Bias 2.0 tool for randomized trials and ROBINS-I for nonrandomized studies. Mean difference (MD) or standardized MD with 95% confidence intervals (CIs) was used to evaluate effect size.
Results: This meta-analysis included 31 studies involving 1359 patients. Compared to arthrocentesis, PRP significantly reduced pain at 6 months (MD, -1.56; 95% CI, -2.68 to -0.44) and improved mandibular movement at 3 months (MD, 2.16; 95% CI, 0.30 to 4.02) and 6 months (MD, 2.56; 95% CI, 0.76 to 4.35). Compared to hyaluronic acid, PRP significantly reduced pain at 3 months (MD, -2.18; 95% CI, -3.70 to -0.66) and improved mandibular movement at 6 months (MD, 3.67; 95% CI, 1.26 to 6.07). Compared to corticosteroids, PRP reduced pain at 1 month (MD, -0.41; 95% CI, -0.81 to -0.02), 3 months (MD, -2.18; 95% CI, -3.70 to -0.66), and 6 months (MD, -1.25; 95% CI, -1.52 to -0.97), and improved mandibular movement at 6 months (MD, 1.46; 95% CI, 0.27 to 2.64).
Conclusions and relevance: PRP injection may be an effective and safe treatment for patients with TMJD. These findings suggest that PRP could serve as a promising minimally invasive option for improving pain and mandibular function in clinical settings.
期刊介绍：
Pain Medicine is a multi-disciplinary journal dedicated to pain clinicians, educators and researchers with an interest in pain from various medical specialties such as pain medicine, anaesthesiology, family practice, internal medicine, neurology, neurological surgery, orthopaedic spine surgery, psychiatry, and rehabilitation medicine as well as related health disciplines such as psychology, neuroscience, nursing, nurse practitioner, physical therapy, and integrative health.
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