Interface between reproductive and metabolic dysfunction in polycystic ovary syndrome.

IF 2.2 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Melody A Rasouli, Jessica Katz, Daniel A Dumesic
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引用次数: 0

Abstract

Purpose of review: New concepts have emerged regarding how interrelationships of hyperandrogenism and hyperinsulinemia from systemic insulin resistance contribute to the origins of polycystic ovary syndrome (PCOS). Although these androgen-insulin interrelationships are associated with several reproductive and metabolic variables, their specific cause and effect relationships remain unclear. This review examines specific causal relationships between hyperandrogenism and hyperinsulinemia from systemic insulin resistance to understand how these complex interactions contribute to the phenotypic expression of PCOS.

Recent findings: Clinical interventions for the treatments of hyperandrogenism and hyperinsulinemia from systemic insulin resistance as well as in-vitro studies of androgen and insulin actions on critical target tissues are examined to understand why androgen-insulin interrelationships are central to the origins of PCOS.

Summary: Bidirectional interrelationships between hyperandrogenism and hyperinsulinemia from systemic insulin resistance in normal-weight PCOS women may have originally evolved as an ancient metabolic adaptation to simultaneously favor fat storage and energy utilization for survival and reproduction during famine. These androgen-insulin interactions in PCOS now predispose to metabolic diseases and pregnancy complications in today's obesogenic environment and, therefore, require improved preventive healthcare to optimize the long-term health of PCOS women and their children.

多囊卵巢综合征中生殖和代谢功能障碍的界面。
综述的目的:关于系统性胰岛素抵抗引起的高雄激素症和高胰岛素血症如何与多囊卵巢综合征(PCOS)的起源相关的新概念已经出现。虽然这些雄激素-胰岛素的相互关系与一些生殖和代谢变量有关,但它们的具体因果关系尚不清楚。本文综述了系统性胰岛素抵抗引起的高雄激素和高胰岛素血症之间的具体因果关系,以了解这些复杂的相互作用如何促进多囊卵巢综合征的表型表达。最近的发现:临床干预治疗高雄激素和高胰岛素血症从全身性胰岛素抵抗,以及体外研究雄激素和胰岛素对关键靶组织的作用,以了解为什么雄激素和胰岛素的相互关系是多囊卵巢综合征的起源的核心。摘要:体重正常的多囊卵巢综合征(PCOS)女性由全身胰岛素抵抗引起的高雄激素和高胰岛素血症之间的双向相互关系,可能最初是进化为一种古老的代谢适应,同时有利于脂肪储存和能量利用,以便在饥荒期间生存和繁殖。在当今的肥胖环境中,多囊卵巢综合征中的雄激素-胰岛素相互作用易导致代谢性疾病和妊娠并发症,因此,需要改进预防保健,以优化多囊卵巢综合征妇女及其子女的长期健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
104
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​Current Opinion in Obstetrics and Gynecology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With eleven disciplines published across the year – including reproductive endocrinology, gynecologic cancer and fertility– every issue also contains annotated references detailing the merits of the most important papers.
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