Tina Zavidić, Ema Dejhalla, Ana Lesac Brizić, Branislava Popović
{"title":"Long-Term Health Consequences of SARS-CoV-2- Trigger for Still Disease in Adults.","authors":"Tina Zavidić, Ema Dejhalla, Ana Lesac Brizić, Branislava Popović","doi":"10.1002/acr2.70042","DOIUrl":null,"url":null,"abstract":"<p><p>Still disease is a rare inflammatory disorder often triggered by infections or malignancies, with SARS-CoV-2 as a possible factor. This paper explores a 56-year-old patient who developed adult-onset Still disease after COVID-19. Symptoms included fever, arthralgia, rash, hepatomegaly, and joint swelling. Diagnosis followed Yamaguchi criteria and treatment with glucocorticoids and immunosuppressants led to recovery. The paper discusses similarities between Still disease and severe COVID-19 that suggest shared inflammatory mechanisms, particularly IL-1 activation. Early diagnosis and treatment are vital. Further research is needed to clarify the link between Still disease and SARS-CoV-2 and improve treatment strategies.</p>","PeriodicalId":93845,"journal":{"name":"ACR open rheumatology","volume":"7 4","pages":"e70042"},"PeriodicalIF":2.8000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014914/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACR open rheumatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/acr2.70042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Still disease is a rare inflammatory disorder often triggered by infections or malignancies, with SARS-CoV-2 as a possible factor. This paper explores a 56-year-old patient who developed adult-onset Still disease after COVID-19. Symptoms included fever, arthralgia, rash, hepatomegaly, and joint swelling. Diagnosis followed Yamaguchi criteria and treatment with glucocorticoids and immunosuppressants led to recovery. The paper discusses similarities between Still disease and severe COVID-19 that suggest shared inflammatory mechanisms, particularly IL-1 activation. Early diagnosis and treatment are vital. Further research is needed to clarify the link between Still disease and SARS-CoV-2 and improve treatment strategies.