Higher resilience in radical cystectomy patients is associated with improved health related quality of life post-operatively.

IF 1 4区医学 Q4 ONCOLOGY

Bladder Cancer Pub Date : 2025-04-13 eCollection Date: 2025-04-01 DOI:10.1177/23523735251319180

Lauren N Kennedy, Caleb S Miller, Danica N May, Evan Fruhauf, Hadley W Wyre, Moben Mirza, Junqiang Dai, Jeffrey M Holzbeierlein, Hayley Stolzle, Moira Mulhern, Mihaela E Sardiu, Eugene K Lee

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引用次数: 0

Abstract

Background: Radical cystectomy (RC) with urinary diversion (UD) is associated with substantial morbidity. Enhanced recovery after surgery protocols, increased robotic usage, and improvements in urinary diversion have been evaluated for their effects on health-related Quality of Life (HRQoL), however, results are mixed. How psychosocial traits inherent to the patient influence HRQoL outcomes is unknown in this population.

Objective: This study aimed to evaluate resilience and its correlation with HRQoL in a cohort of patients undergoing RC for bladder cancer.

Methods: Patients with bladder cancer undergoing RC with UD at the University of Kansas Medical Center were screened for prospective enrollment in this clinical trial (NCT06337305). The validated Connor-Davidson Resilience Scale 25 (CD-RISC), the Functional Assessment of Cancer Therapy-Bladder-Cystectomy (FACT-BL-Cys), and the PROMIS 29-v2.0 were administered preoperatively, 2-3 weeks postoperatively, and at 90 days postoperatively. Patient demographics, pathology, and complication data were collected.

Results: Between November 2020 and August 2022, 52 patients completed the survey data. Patients were stratified based on baseline resilience score. The higher resilience group scored 85.7, 85.0, and 81.9 compared to 64.9, 70.4, and 72.0 at the three time points which all remained statistically significant. Participant resilience scores using the CD-RISC did not correlate with quality-of-life measures using the PROMIS or FACT-Bl-Cys at baseline or two weeks but did correlate at 90 days (p < 0.01). Resilience did not correlate with the patient's pathology stage or 90-day complication data.

Conclusions: Patients with higher baseline resilience maintain higher levels throughout the perioperative period and correlate with QOL.

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根治性膀胱切除术患者较高的恢复力与术后健康相关生活质量的改善相关。

背景：根治性膀胱切除术（RC）合并尿分流（UD）与大量的发病率相关。手术后恢复的增强、机器人使用的增加和尿分流的改善对健康相关生活质量（HRQoL）的影响进行了评估，然而，结果好坏参半。在这一人群中，患者固有的社会心理特征如何影响HRQoL结果尚不清楚。目的：本研究旨在评估膀胱癌患者接受RC治疗后的恢复力及其与HRQoL的相关性。方法：对在堪萨斯大学医学中心接受RC合并UD的膀胱癌患者进行前瞻性筛选，纳入该临床试验（NCT06337305）。术前、术后2-3周和术后90天分别使用经验证的Connor-Davidson弹性量表25 （CD-RISC）、肿瘤治疗功能评估-膀胱切除术（FACT-BL-Cys）和PROMIS 29-v2.0。收集患者人口统计、病理和并发症数据。结果：2020年11月至2022年8月，52例患者完成了调查数据。根据基线恢复力评分对患者进行分层。高弹性组在三个时间点的得分分别为85.7、85.0和81.9，而高弹性组在三个时间点的得分分别为64.9、70.4和72.0，这三个时间点的得分均具有统计学意义。在基线或两周时，使用CD-RISC的参与者恢复力评分与使用PROMIS或fact - b - cys的生活质量测量不相关，但在90天时确实相关(p)。结论：基线恢复力较高的患者在整个围手术期保持较高的水平，并与生活质量相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bladder Cancer Medicine-Urology

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： Bladder Cancer is an international multidisciplinary journal to facilitate progress in understanding the epidemiology/etiology, genetics, molecular correlates, pathogenesis, pharmacology, ethics, patient advocacy and survivorship, diagnosis and treatment of tumors of the bladder and upper urinary tract. The journal publishes research reports, reviews, short communications, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research in basic science, translational research and clinical medicine that expedites our fundamental understanding and improves treatment of tumors of the bladder and upper urinary tract.