The Significance of Screening Endoscopy at 2-Year Interval for Detecting Pharyngeal and Esophageal Cancer in the Japanese General Population.

IF 1.6 Q4 ONCOLOGY

Journal of Gastrointestinal Cancer Pub Date : 2025-05-10 DOI:10.1007/s12029-025-01243-7

Kazuhiro Kashiwagi, Toshifumi Yoshida, Satoshi Kinoshita, Hiromasa Nakamizo, Rieko Nakamura, Hiromasa Takaishi, Yasushi Iwao, Takanori Kanai

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引用次数: 0

Abstract

Purpose: We previously identified examination time and 2-year interval as effective quality indicators for detecting upper gastrointestinal cancer during screening esophagogastroduodenoscopy (EGD). We evaluated the significance of biennial endoscopy in detecting pharyngeal and esophageal cancer.

Methods: Individuals who underwent multiple EGD examinations as health checkups at our center between August 2012 and January 2022 were included. Endoscopists were categorized into two groups based on their mean examination time for normal EGD findings, using a threshold of 5 min. The associations between cancer detection rate and these indicators were analyzed using multivariable analyses.

Results: Twelve endoscopists performed more than 1000 examinations each, for a total of 28,842 examinations, detecting all (6 pharyngeal and 26 esophageal) cancers. Intervals between endoscopies were classified into three groups: ≤ 1 year (Group 1), 1 to ≤ 2 years (Group 2), and > 2 years (Group 3). This cancer detection rate did not differ significantly between Groups 1 and 2 (p = 0.761) but was significantly higher in Group 3 than in Group 2 (OR = 4.356, 95% CI = 1.161-16.333, p = 0.029). When Groups 1 and 2 were combined (≤ 2 years) and compared with Group 3, an interval of > 2 years was significantly associated with a higher detection rate, including cases not curable by endoscopic resection (OR, 4.710; 95% CI, 1.806-12.282; p = 0.002). Examination time was not associated with the cancer detection rate (p = 0.944).

Conclusions: These findings support the significance of biennial endoscopy in detecting pharyngeal and esophageal cancer as well.

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在日本普通人群中，2年一次的内镜筛查对检测咽喉癌和食管癌的意义。

目的：我们之前将检查时间和2年间隔作为食管胃十二指肠镜（EGD）筛查中发现上消化道肿瘤的有效质量指标。我们评估两年一次的内镜检查在检测咽喉癌和食管癌中的意义。方法：纳入2012年8月至2022年1月期间在我中心进行多次EGD体检的个体。内镜医师根据正常EGD发现的平均检查时间分为两组，阈值为5分钟。使用多变量分析分析癌症检出率与这些指标之间的关系。结果：12名内镜医师每人检查1000余次，检查28842例，全部发现（咽喉癌6例，食管癌26例）。内镜检查间隔时间分为≤1年组（1组）、1 ~≤2年组（2组）、bb0 ~ 2年组（3组）。1组和2组之间的癌症检出率无显著差异（p = 0.761），但3组的癌症检出率明显高于2组（OR = 4.356, 95% CI = 1.161 ~ 16.333, p = 0.029）。当第1组和第2组合并（≤2年）时，与第3组相比，间隔> - 2年与更高的检出率显著相关，包括内镜切除无法治愈的病例(OR, 4.710；95% ci, 1.806-12.282；p = 0.002)。检查时间与肿瘤检出率无相关性（p = 0.944）。结论：两年一次的内镜检查对咽喉癌和食管癌的诊断具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastrointestinal Cancer ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

121

期刊介绍： The Journal of Gastrointestinal Cancer is a multidisciplinary medium for the publication of novel research pertaining to cancers arising from the gastrointestinal tract.The journal is dedicated to the most rapid publication possible.The journal publishes papers in all relevant fields, emphasizing those studies that are helpful in understanding and treating cancers affecting the esophagus, stomach, liver, gallbladder and biliary tree, pancreas, small bowel, large bowel, rectum, and anus. In addition, the Journal of Gastrointestinal Cancer publishes basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. New insights are provided from diverse areas of research such as studies exploring pre-neoplastic states, risk factors, epidemiology, genetics, preclinical therapeutics, surgery, radiation therapy, novel medical therapeutics, clinical trials, and outcome studies.In addition to reports of original clinical and experimental studies, the journal also publishes: case reports, state-of-the-art reviews on topics of immediate interest or importance; invited articles analyzing particular areas of pancreatic research and knowledge; perspectives in which critical evaluation and conflicting opinions about current topics may be expressed; meeting highlights that summarize important points presented at recent meetings; abstracts of symposia and conferences; book reviews; hypotheses; Letters to the Editors; and other items of special interest, including:Complex Cases in GI Oncology: This is a new initiative to provide a forum to review and discuss the history and management of complex and involved gastrointestinal oncology cases. The format will be similar to a teaching case conference where a case vignette is presented and is followed by a series of questions and discussion points. A brief reference list supporting the points made in discussion would be expected.