Ubiquitin proteasome system (UPS): a crucial determinant of the epigenetic landscape in cancer.

IF 3 4区 医学 Q2 GENETICS & HEREDITY
Srija Roy, Mrinal K Ghosh
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引用次数: 0

Abstract

The ubiquitin proteasome system (UPS), comprising of ubiquitinases, deubiquitinases and 26S proteasome plays a significant role in directly or indirectly regulating epigenetic players. DNA-templated processes like replication, repair and transcription require chromatin decondensation to allow access to specific DNA sequence. A thorough survey of literary articles in PubMed database revealed that the UPS functions as a key regulator, determining the precise state of open and closed chromatin by influencing histones and histone modifiers through proteolytic or non-proteolytic means. However, a comprehensive understanding of how specific UPS components affect particular epigenetic pathways in response to environmental cues remains underexplored. This axis holds substantial potential for deciphering mechanisms of tumorigenesis. Although our current knowledge is limited, it can still guide the development of novel therapeutic strategies that can potentially bridge the gap between cancer chemotherapeutics in bench and bedside.

泛素蛋白酶体系统(UPS):癌症表观遗传景观的关键决定因素。
由泛素酶、去泛素酶和26S蛋白酶体组成的泛素蛋白酶体系统(ubiquitin proteasome system, UPS)在直接或间接调节表观遗传因子中起重要作用。DNA模板化的过程,如复制、修复和转录,需要染色质去浓缩才能进入特定的DNA序列。通过对PubMed数据库文献的全面调查,我们发现UPS作为一个关键的调节因子,通过蛋白水解或非蛋白水解的方式影响组蛋白和组蛋白修饰因子,从而决定染色质打开和关闭的精确状态。然而,对特定UPS组件如何影响特定表观遗传途径以响应环境线索的全面理解仍未得到充分探索。这条轴具有破译肿瘤发生机制的巨大潜力。虽然我们目前的知识是有限的,但它仍然可以指导新的治疗策略的发展,这些策略可以潜在地弥合癌症化疗在实验室和床边之间的差距。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Epigenomics
Epigenomics GENETICS & HEREDITY-
CiteScore
5.80
自引率
2.60%
发文量
95
审稿时长
>12 weeks
期刊介绍: Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.
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