Assessment of the acute impact of high and low dose vanadyl sulphate in a high fructose metabolic syndrome rat model.

Abstract

Obesity and type 2 diabetes are pathologies that are difficult to control, especially in older individuals; therefore, there is extensive research for the development of new hypoglycemic and lipid-lowering drugs, among them, insulin in diabetic patients has an immediate hypoglycemic effect. Some vanadium derivatives induce a decrease in body weight and blood concentrations of glucose, triglycerides, and cholesterol, after being administered for a few weeks in humans and in animal models with metabolic syndrome (MetS), which is called 'insulin-like effect' of vanadium compounds. The aim of this work is to analyse the immediate effects of vanadyl sulfate (VS) on blood glucose, triglycerides and cholesterol levels in old rats with MetS. MetS was induced in male Wistar rats by a high-fructose diet (HFD) for 20 weeks. Then, in week 22, rats were treated with one dose of VS, and at minutes 0, 15, 30, 60, 90, 120, 150, 180, and 24 hours later blood samples were taken for biochemistry analysis. VS in rats with MetS causes a slight blood glucose increase in the first 30 minutes and then drops to normal concentrations without causing hypoglycemia, remaining normal for 24 hours. Insulin decreases to normal levels. Cholesterol decreases progressively from the first 15 minutes, remaining low after 24 hours, while triglycerides increase slightly during the first three hours, but after 24 hours, it has decreased. VS in rats with MetS, causes a decrease in the consumption of sugared water and food from the first 24 hours.