Synergistic factors impacting quality-adjusted life years in the frail elderly population

Revista clinica espanola Pub Date : 2025-06-01 DOI:10.1016/j.rceng.2025.502297

L.S. Briongos Figuero , J.P. Miramontes González , M. Gabella Martín , L. Corral Gudino , G. López Muñiz , J.C. Martín Escudero

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Abstract

Introduction

We aim to analyse which factors predominantly influence the QALYs related to geriatric frailty syndrome (QALYs-frail) in octogenarians.

Materials and methods

Prospective observational study of 63 frail octogenarian patients admitted to the medical area. Clinical-demographic variables were collected, as well as quality of life (EuroQoL-5D-5L), nutritional status (MNA-SF), dependence (Barthel scale), comorbidity, and the ADLs related to frailty. Statistical models were carried out to study the association between the different variables and to find predictive factors.

Results

Patients with better nutritional status showed a positive correlation with the AVACs-frail (r = 0.4, p = 0.003), as did patients with a lower degree of dependence (r = 0.71, p < 0.001). When adding multimorbidity, a significant negative correlation was identified (r = −0.16, p = 0.002). The same happened with age (r = −0.43, p < 0.001).

Conclusions

Managing fragility poses a challenge, but specific interventions could have an impactful and cost-effective effect on this vulnerable subgroup of the population.

查看原文本刊更多论文

影响体弱老年人群质量调整寿命年的协同因素。

前言：我们的目的是分析哪些因素主要影响与老年衰弱综合征（QALYs-虚弱）相关的80多岁老人的QALYs。材料与方法：对63例老年体弱患者进行前瞻性观察研究。收集临床人口学变量，以及生活质量（EuroQoL-5D-5L）、营养状况（MNA-SF）、依赖性（Barthel量表）、合并症和与衰弱相关的adl。采用统计模型研究不同变量之间的关系，寻找预测因素。结果：营养状况较好的患者与avacs -虚弱呈正相关（r=0.4, p=0.003），依赖程度较低的患者也是如此（r=0.71, p）结论：管理脆弱性是一项挑战，但具体的干预措施可能对这一弱势人群产生有效且具有成本效益的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista clinica espanola

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