Safe and effective use of vancomycin.

IF 4.2 Q2 PHARMACOLOGY & PHARMACY
Amy Legg, Felicia Devchand, Amanda Gwee, Indy Sandaradura, Tony Lai
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引用次数: 0

Abstract

Vancomycin is an important antimicrobial for prophylactic, empirical and directed therapy of Gram-positive organisms. Therapeutic drug monitoring is recommended for all patients expected to receive vancomycin for more than 48 hours to optimise drug exposure. Monitoring the area under the concentration-time curve over a 24-hour period (AUC24) for vancomycin is preferred over monitoring trough plasma concentrations. An AUC24 of 400 to 600 mg.hr/L is recommended for infections other than central nervous system infections. Vancomycin may cause nephrotoxicity, ototoxicity, cutaneous reactions, hypersensitivity and haematological toxicity. Reducing the incidence of vancomycin-induced nephrotoxicity involves recognising and modifying risk factors where possible.

万古霉素的安全有效使用。
万古霉素是一种重要的抗微生物药物,可用于革兰氏阳性菌的预防性、经验性和定向治疗。建议所有预期接受万古霉素治疗超过48小时的患者进行治疗性药物监测,以优化药物暴露。在24小时内监测万古霉素浓度-时间曲线下的面积(AUC24)比监测血浆浓度更可取。AUC24是400到600毫克。hr/L推荐用于除中枢神经系统感染以外的感染。万古霉素可能引起肾毒性、耳毒性、皮肤反应、过敏和血液毒性。减少万古霉素引起的肾毒性的发生率包括在可能的情况下识别和改变危险因素。
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来源期刊
Australian Prescriber
Australian Prescriber MEDICINE, GENERAL & INTERNAL-PHARMACOLOGY & PHARMACY
CiteScore
3.80
自引率
7.40%
发文量
71
审稿时长
>12 weeks
期刊介绍: Australian Prescriber is Australia''s free, national, independent journal of drugs and therapeutics. It is published every two months online. Our purpose is to help health professionals make informed choices when prescribing, including whether to prescribe a drug or not. To do this we provide independent, reliable and accessible information. As well as publishing short didactic reviews, we facilitate debate about complex, controversial or uncertain therapeutic areas. We are part of NPS MedicineWise, an independent, non-profit organisation providing medicines information and resources for health professionals, and stakeholders involved in the quality use of medicines. NPS MedicineWise is funded by the Australian Government Department of Health.
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