Recombinant Antimicrobial Peptides (rAMPs); Potential Applications in Medicine and Veterinary Medicine: A Review.

IF 1.6 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Amir Asghari Baghkheirati, Reza Golmohammadi, Mohammad Hadi Sekhavati, Jamshid Razmyar, Mohammad Ali Abyazi
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引用次数: 0

Abstract

Antibiotic resistance has become a major public health concern worldwide. Treatment of humans and animals is becoming increasingly challenging due to antibiotic resistance. Antibiotic-resistant bacteria can be transmitted from animals to humans by several routes, including direct contact, contaminated food or water, or environmental exposure. Various factors contribute to the rising problem, such as the widespread and indiscriminate exploitation of antimicrobials in both human and animal healthcare, over-prescription, misuse of antibiotics, the role of agriculture in spreading antibiotic resistance, and poor animal husbandry practices. According to the preliminary findings, recombinant antimicrobial peptides are an interesting novel area of biotechnology and medical innovation that might be employed as a secure and effective substitute for antibiotics. In this review study, we briefly examine the factors contributing to the rise of antibiotic resistance. We then introduce and discuss recombinant antimicrobial peptides as a promising strategy to address this growing problem.

重组抗菌肽(rAMPs);医学和兽医学的潜在应用综述
抗生素耐药性已成为世界范围内一个主要的公共卫生问题。由于抗生素耐药性,人类和动物的治疗变得越来越具有挑战性。耐抗生素细菌可通过几种途径从动物传播给人类,包括直接接触、受污染的食物或水或环境暴露。各种因素导致了这一日益严重的问题,例如在人类和动物保健中广泛和不分青红皂白地使用抗菌素、过度处方、滥用抗生素、农业在传播抗生素耐药性方面的作用以及不良的畜牧业做法。根据初步研究结果,重组抗菌肽是生物技术和医学创新的一个有趣的新领域,可能被用作抗生素的安全有效的替代品。在这篇综述研究中,我们简要地研究了导致抗生素耐药性上升的因素。然后我们介绍和讨论重组抗菌肽作为一个有希望的策略来解决这一日益严重的问题。
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来源期刊
Iranian Journal of Biotechnology
Iranian Journal of Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
CiteScore
2.60
自引率
7.70%
发文量
20
期刊介绍: Iranian Journal of Biotechnology (IJB) is published quarterly by the National Institute of Genetic Engineering and Biotechnology. IJB publishes original scientific research papers in the broad area of Biotechnology such as, Agriculture, Animal and Marine Sciences, Basic Sciences, Bioinformatics, Biosafety and Bioethics, Environment, Industry and Mining and Medical Sciences.
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