Inflammatory and Antioxidant Status in Peri-Implant Health and Diseases: A Biochemical Analysis.

Q3 Dentistry

Journal of long-term effects of medical implants Pub Date : 2025-01-01 DOI:10.1615/JLongTermEffMedImplants.2025052691

Poulami Chakraborty, Arvina Rajasekar

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引用次数: 0

Abstract

Background: Peri-implant disease pathogenesis results in production of pro-inflammatory mediators. These mediators alter the redox balance leading to decrease in antioxidants. The aim of the study was to compare the levels of interleukin-6 (IL-6) and superoxide dismutase (SOD) in peri-implant health and diseases.

Materials and methods: The present observational study was carried out from March 2023 to September 2023 in the Department of Implantology, Saveetha Dental College and Hospitals, Chennai, India. A total of 60 patients with peri-implant health (n = 20), peri-implant mucositis (n = 20) and peri-implantitis (n = 20) were enrolled. Unstimulated salivary samples were collected and subjected to ELISA for IL-6 and SOD analysis. IL-6 and SOD levels were then compared between the groups using ANOVA.

Results: There was a statistically significant difference in IL-6 and SOD levels between the three groups with p value of 0.003 and 0.000 respectively.

Conclusion: The present study suggests that IL-6 level increases and SOD level decreases with severity of peri-implant diseases.

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种植体周围健康和疾病中的炎症和抗氧化状态：生化分析。

背景：种植体周围疾病的发病机制导致促炎介质的产生。这些介质改变氧化还原平衡，导致抗氧化剂减少。本研究的目的是比较种植体周围健康和疾病中白细胞介素-6 （IL-6）和超氧化物歧化酶（SOD）的水平。材料与方法：本观察性研究于2023年3月至2023年9月在印度金奈Saveetha牙科学院和医院种植科进行。共纳入60例种植体周围健康（n = 20）、种植体周围粘膜炎（n = 20）和种植体周围炎（n = 20）患者。采集未受刺激的唾液标本，采用ELISA法检测IL-6和SOD。然后用方差分析比较各组间IL-6和SOD水平。结果：三组患者IL-6、SOD水平差异均有统计学意义，p值分别为0.003、0.000。结论：随着种植体周围病变的严重程度，IL-6水平升高，SOD水平降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of long-term effects of medical implants Dentistry-Dentistry (all)

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： MEDICAL IMPLANTS are being used in every organ of the human body. Ideally, medical implants must have biomechanical properties comparable to those of autogenous tissues without any adverse effects. In each anatomic site, studies of the long-term effects of medical implants must be undertaken to determine accurately the safety and performance of the implants. Today, implant surgery has become an interdisciplinary undertaking involving a number of skilled and gifted specialists. For example, successful cochlear implants will involve audiologists, audiological physicians, speech and language therapists, otolaryngologists, nurses, neuro-otologists, teachers of the deaf, hearing therapists, cochlear implant manufacturers, and others involved with hearing-impaired and deaf individuals.