Gamma Knife Radiosurgery for Glossopharyngeal Neuralgia: A Retrospective Study.

IF 1.9 4区医学 Q3 NEUROIMAGING

Stereotactic and Functional Neurosurgery Pub Date : 2025-04-18 DOI:10.1159/000545986

Andrea Franzini, Piero Picozzi, Zefferino Rossini, Maria Pia Tropeano, Beatrice Claudia Bono, Ali Baram, Pierina Navarria, Federico Pessina

{"title":"Gamma Knife Radiosurgery for Glossopharyngeal Neuralgia: A Retrospective Study.","authors":"Andrea Franzini, Piero Picozzi, Zefferino Rossini, Maria Pia Tropeano, Beatrice Claudia Bono, Ali Baram, Pierina Navarria, Federico Pessina","doi":"10.1159/000545986","DOIUrl":null,"url":null,"abstract":"Background: The treatment of patients with glossopharyngeal neuralgia (GN) refractory to medical therapies is challenging. Gamma Knife Radiosurgery (GKRS) has emerged as an incisionless treatment option with outcomes reported in a limited number of studies.Objectives: To report on the outcomes of GKRS in patients with GN treated at our center.Methods: We retrospectively reviewed all patients with GN who underwent GKRS at our center since 2017. Pain intensity was evaluated using the Barrow Neurological Institute (BNI) pain score modified for GN. Adverse events were recorded.Results: Six patients underwent GKRS for GN at our center between 2017 and 2024. The maximum dose delivered was 85Gy for one patient and 90 Gy for the others. After a median period of 2 weeks from GKRS, all patients experienced pain reduction (BNI I-IIIa). Pain recurred during follow-up in two patients after 9 and 3 months, respectively. Both underwent repeat GKRS, which relieved pain in one. No adverse event or neurological deficit occurred.Conclusions: GKRS is an effective, well-tolerated treatment for patients with GN. Pain may recur over time, but more durable pain relief can be achieved with repeat GKRS.","PeriodicalId":22078,"journal":{"name":"Stereotactic and Functional Neurosurgery","volume":" ","pages":"1-17"},"PeriodicalIF":1.9000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stereotactic and Functional Neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000545986","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROIMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The treatment of patients with glossopharyngeal neuralgia (GN) refractory to medical therapies is challenging. Gamma Knife Radiosurgery (GKRS) has emerged as an incisionless treatment option with outcomes reported in a limited number of studies.

Objectives: To report on the outcomes of GKRS in patients with GN treated at our center.

Methods: We retrospectively reviewed all patients with GN who underwent GKRS at our center since 2017. Pain intensity was evaluated using the Barrow Neurological Institute (BNI) pain score modified for GN. Adverse events were recorded.

Results: Six patients underwent GKRS for GN at our center between 2017 and 2024. The maximum dose delivered was 85Gy for one patient and 90 Gy for the others. After a median period of 2 weeks from GKRS, all patients experienced pain reduction (BNI I-IIIa). Pain recurred during follow-up in two patients after 9 and 3 months, respectively. Both underwent repeat GKRS, which relieved pain in one. No adverse event or neurological deficit occurred.

Conclusions: GKRS is an effective, well-tolerated treatment for patients with GN. Pain may recur over time, but more durable pain relief can be achieved with repeat GKRS.

查看原文本刊更多论文

伽玛刀放射治疗舌咽神经痛的回顾性研究。

背景：药物治疗难治性舌咽神经痛（GN）患者的治疗具有挑战性。伽玛刀放射外科（GKRS）已成为一种无切口治疗选择，其结果在有限数量的研究中报道。目的：报道本中心治疗的GN患者GKRS的结果。方法：我们回顾性分析了自2017年以来在我们中心接受GKRS的所有GN患者。疼痛强度评估采用巴罗神经学研究所（BNI）疼痛评分修改GN。记录不良事件。结果：2017年至2024年，6例患者在我中心接受GKRS治疗GN。一名患者的最大剂量为85戈瑞，其他患者为90戈瑞。GKRS的中位期为2周后，所有患者都经历了疼痛减轻（BNI I-IIIa）。2例患者分别在随访9个月和3个月后疼痛复发。两人都接受了重复GKRS，其中一人的疼痛得到缓解。未发生不良事件或神经功能缺损。结论：GKRS是一种有效且耐受性良好的治疗方法。疼痛可能会随着时间的推移而复发，但通过重复GKRS可以实现更持久的疼痛缓解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Stereotactic and Functional Neurosurgery 医学-神经成像

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： ''Stereotactic and Functional Neurosurgery'' provides a single source for the reader to keep abreast of developments in the most rapidly advancing subspecialty within neurosurgery. Technological advances in computer-assisted surgery, robotics, imaging and neurophysiology are being applied to clinical problems with ever-increasing rapidity in stereotaxis more than any other field, providing opportunities for new approaches to surgical and radiotherapeutic management of diseases of the brain, spinal cord, and spine. Issues feature advances in the use of deep-brain stimulation, imaging-guided techniques in stereotactic biopsy and craniotomy, stereotactic radiosurgery, and stereotactically implanted and guided radiotherapeutics and biologicals in the treatment of functional and movement disorders, brain tumors, and other diseases of the brain. Background information from basic science laboratories related to such clinical advances provides the reader with an overall perspective of this field. Proceedings and abstracts from many of the key international meetings furnish an overview of this specialty available nowhere else. ''Stereotactic and Functional Neurosurgery'' meets the information needs of both investigators and clinicians in this rapidly advancing field.