Trends in the Incidence of Type 1 Diabetes in European Children and Adolescents from 1994 to 2022: A Systematic Review and Meta-Analysis.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Pediatric Diabetes Pub Date : 2024-05-27 eCollection Date: 2024-01-01 DOI:10.1155/2024/2338922

Marta Carolina Ruiz-Grao, Ana Díez-Fernández, Arthur E Mesas, Vicente Martínez-Vizcaíno, Irene Sequí-Domínguez, Fernando Sebastián-Valles, Miriam Garrido-Miguel

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引用次数: 0

Abstract

Aim: To assess the incidence trends in type 1 diabetes among children and adolescents across Europe during the period from 1994 to 2022 using a systematic methodology.

Materials and methods: Cross-sectional or follow-up studies reporting population-based incidence rates (IRs) of European children and adolescents diagnosed aged <15 years with type 1 diabetes were included. The Mantel‒Haenszel or DerSimonian and Laird random-effects method was used to compute the pooled IR estimates and their 95% confidence intervals (CIs). Subgroup analyses were conducted by study year, biological sex, age group (0-4, 5-9, and 10-14 years), country, and European regions.

Results: A total of 75 studies (219,331 children and adolescents aged 0-14 years) with data from 32 countries were included. Generally, a high overall rate of increase in type 1 diabetes incidence has been shown in most European countries from 1994 to 2022 in both sexes, with an overall increase from 10.85 (95% CI, 9.62-12.07) per 100,000 person-years from 1994 to 2003 to 20.96 (95% CI, 19.26-22.66) per 100,000 person-years from 2013 to 2022.

Conclusions: There are substantial between-country differences in the current levels and trends of IR in type 1 diabetes in European children and adolescents. Our data suggest a worrying upward trend in most European countries.

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1994年至2022年欧洲儿童和青少年1型糖尿病发病率趋势：系统回顾和荟萃分析

目的：采用系统方法评估1994年至2022年欧洲儿童和青少年1型糖尿病的发病率趋势。材料和方法：横断面或随访研究报告了诊断为老年的欧洲儿童和青少年基于人群的发病率（IRs）。结果：共纳入75项研究（219331名0-14岁儿童和青少年），数据来自32个国家。总体而言，从1994年到2022年，大多数欧洲国家的1型糖尿病发病率在两性中都呈现出较高的总体增长率，从1994年至2003年每10万人年10.85例（95% CI, 9.62-12.07）增加到2013年至2022年每10万人年20.96例（95% CI, 19.26-22.66）。结论：欧洲儿童和青少年1型糖尿病患者的IR水平和趋势在不同国家之间存在显著差异。我们的数据显示，大多数欧洲国家出现了令人担忧的上升趋势。

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来源期刊

Pediatric Diabetes 医学-内分泌学与代谢

CiteScore

6.60

自引率

14.70%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Pediatric Diabetes is a bi-monthly journal devoted to disseminating new knowledge relating to the epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The aim of the journal is to become the leading vehicle for international dissemination of research and practice relating to diabetes in youth. Papers are considered for publication based on the rigor of scientific approach, novelty, and importance for understanding mechanisms involved in the epidemiology and etiology of this disease, especially its molecular, biochemical and physiological aspects. Work relating to the clinical presentation, course, management and outcome of diabetes, including its physical and emotional sequelae, is considered. In vitro studies using animal or human tissues, whole animal and clinical studies in humans are also considered. The journal reviews full-length papers, preliminary communications with important new information, clinical reports, and reviews of major topics. Invited editorials, commentaries, and perspectives are a regular feature. The editors, based in the USA, Europe, and Australasia, maintain regular communications to assure rapid turnaround time of submitted manuscripts.