Altered brain function and structure in youth-onset type 2 diabetes.

IF 5.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Allison L B Shapiro, Phoom Narongkiatikhun, Ye Ji Choi, Greta Wilkening, Kalie L Tommerdahl, Hailey E Hamson, Laura Pyle, Petter Bjornstad
{"title":"Altered brain function and structure in youth-onset type 2 diabetes.","authors":"Allison L B Shapiro, Phoom Narongkiatikhun, Ye Ji Choi, Greta Wilkening, Kalie L Tommerdahl, Hailey E Hamson, Laura Pyle, Petter Bjornstad","doi":"10.1093/ejendo/lvaf098","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Despite the aggressive clinical trajectory of youth-onset type 2 diabetes (Y-T2D) and consistent evidence of cognitive dysfunction and poor brain health in adults with T2D, the impact of Y-T2D on brain function and structure is understudied.</p><p><strong>Design: </strong>This study aimed to characterize brain function and structure in a cross-sectional sample of young people with Y-T2D and compare these brain attributes to peers with obesity alone (OB) or healthy weight (HW) without T2D.</p><p><strong>Methods: </strong>Brain structure and function were measured via magnetic resonance imaging. Functional connectivity was estimated with a seed-to-voxel analysis and gray matter (GM) volume differences explored between groups.</p><p><strong>Results: </strong>Forty young adult participants were included (Y-T2D: n = 12, mean [±SD] age 25.0 ± 7.2 years, diabetes duration 6.5 ± 6.7 years; OB: n = 8, age 19 ± 1.6 years; HW: n = 20, age 22.9 ± 4.1 years). The Y-T2D group showed stronger functional connectivity between the salience network and default mode network, compared to both the OB and HW groups (P < .05 for all, respectively). The Y-T2D group had reduced GM volume in regions associated with executive functioning, language, and visual processing relative to the OB and HW groups (P < .001 for all, respectively).</p><p><strong>Conclusions: </strong>Y-T2D is associated with distinct alterations in brain function and structure, providing evidence of potentially compromised brain health in this clinical population.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":" ","pages":"671-679"},"PeriodicalIF":5.3000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100494/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ejendo/lvaf098","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: Despite the aggressive clinical trajectory of youth-onset type 2 diabetes (Y-T2D) and consistent evidence of cognitive dysfunction and poor brain health in adults with T2D, the impact of Y-T2D on brain function and structure is understudied.

Design: This study aimed to characterize brain function and structure in a cross-sectional sample of young people with Y-T2D and compare these brain attributes to peers with obesity alone (OB) or healthy weight (HW) without T2D.

Methods: Brain structure and function were measured via magnetic resonance imaging. Functional connectivity was estimated with a seed-to-voxel analysis and gray matter (GM) volume differences explored between groups.

Results: Forty young adult participants were included (Y-T2D: n = 12, mean [±SD] age 25.0 ± 7.2 years, diabetes duration 6.5 ± 6.7 years; OB: n = 8, age 19 ± 1.6 years; HW: n = 20, age 22.9 ± 4.1 years). The Y-T2D group showed stronger functional connectivity between the salience network and default mode network, compared to both the OB and HW groups (P < .05 for all, respectively). The Y-T2D group had reduced GM volume in regions associated with executive functioning, language, and visual processing relative to the OB and HW groups (P < .001 for all, respectively).

Conclusions: Y-T2D is associated with distinct alterations in brain function and structure, providing evidence of potentially compromised brain health in this clinical population.

青少年发病2型糖尿病的脑功能和结构改变。
目的:尽管年轻发病的2型糖尿病(Y-T2D)具有侵袭性的临床轨迹,并且有一致的证据表明,成年T2D患者存在认知功能障碍和大脑健康状况不佳,但Y-T2D对大脑功能和结构的影响尚未得到充分研究。设计:本研究旨在描述y型T2D年轻人的脑功能和结构,并将这些脑属性与单纯肥胖(OB)或健康体重(HW)无T2D的同龄人进行比较。方法:采用核磁共振成像技术测量脑结构和功能。通过种子到体素的分析来估计功能连通性,并探索组间灰质(GM)体积差异。结果:纳入40名青年参与者(Y-T2D: n=12,平均[±SD]年龄25.0±7.2岁,糖尿病病程6.5±6.7年;OB: 8例,年龄19±1.6岁;HW: n=20,年龄22.9±4.1岁)。与OB和HW组相比,Y-T2D组在突出网络和默认模式网络之间显示出更强的功能连接(结论:Y-T2D与大脑功能和结构的明显改变有关,为该临床人群的大脑健康潜在受损提供了证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
European Journal of Endocrinology
European Journal of Endocrinology 医学-内分泌学与代谢
CiteScore
9.80
自引率
3.40%
发文量
354
审稿时长
1 months
期刊介绍: European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信