Evaluating feature extraction reproducibility across image biomarker standardization initiative-compliant radiomics platforms using a digital phantom.

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Han-Back Shin, Heesoon Sheen, Jang-Hoon Oh, Young Eun Choi, Kihoon Sung, Hyun Ju Kim
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引用次数: 0

Abstract

Background: The aim of this study was to thoroughly analyze the reproducibility of radiomics feature extraction across three Image Biomarker Standardization Initiative (IBSI)-compliant platforms using a digital phantom for benchmarking. It uncovers high consistency among common features while also pointing out the necessity for standardization in computational algorithms and mathematical definitions due to unique platform-specific features.

Methods: We selected three widely used radiomics platforms: LIFEx, Computational Environment for Radiological Research (CERR), and PyRadiomics. Using the IBSI digital phantom, we performed a comparative analysis to extract and benchmark radiomics features. The study design included testing each platform's ability to consistently reproduce radiomics features, with statistical analyses to assess the variability and agreement among the platforms.

Results: The results indicated varying levels of feature reproducibility across the platforms. Although some features showed high consistency, others varied significantly, highlighting the need for standardized computational algorithms. Specifically, LIFEx and PyRadiomics performed consistently well across many features, whereas CERR showed greater variability in certain feature categories than LIFEx and PyRadiomics.

Conclusion: The study findings highlight the need for harmonized feature calculation methods to enhance the reliability and clinical usefulness of radiomics. Additionally, this study recommends incorporating clinical data and establishing benchmarking procedures in future studies to enhance the role of radiomics in personalized medicine.

使用数字幻影评估图像生物标志物标准化倡议兼容放射组学平台的特征提取再现性。
背景:本研究的目的是全面分析放射组学特征提取在三个图像生物标志物标准化倡议(IBSI)兼容平台上的可重复性,使用数字模型进行基准测试。它揭示了共同特征之间的高度一致性,同时也指出了由于独特的平台特定特征而导致计算算法和数学定义标准化的必要性。方法:我们选择了三个广泛使用的放射组学平台:LIFEx,计算环境放射研究(CERR)和PyRadiomics。使用IBSI数字幻影,我们进行了比较分析,以提取和基准放射组学特征。研究设计包括测试每个平台一致再现放射组学特征的能力,并通过统计分析来评估平台之间的可变性和一致性。结果:结果表明不同平台的特征重现性不同。尽管一些特征显示出高度一致性,但其他特征差异很大,这突出了对标准化计算算法的需求。具体来说,LIFEx和PyRadiomics在许多特征上表现一致,而CERR在某些特征类别上表现出比LIFEx和PyRadiomics更大的变异性。结论:研究结果强调需要统一的特征计算方法来提高放射组学的可靠性和临床实用性。此外,本研究建议在未来的研究中纳入临床数据并建立基准程序,以增强放射组学在个性化医疗中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
自引率
19.00%
发文量
331
审稿时长
3 months
期刊介绍: Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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