Neurological Manifestations of Patients With CNS Metastases: Experience From a Single Center in an Upper-Middle-Income Country.

IF 3 Q2 ONCOLOGY

JCO Global Oncology Pub Date : 2025-04-01 Epub Date: 2025-04-23 DOI:10.1200/GO-24-00465

Bernardo Cacho-Díaz, Alberto González-Aguilar, Gervith Reyes-Soto, José O Navarro-Fernández, Federico Maldonado-Magos, Oscar Arrieta, Talia Wegman-Ostrosky, Orwa Aboud, Mónica Serrano-Murillo

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Abstract

Purpose: This study aimed to report the neurological manifestations of patients with CNS metastases (CNSm) and to determine their association with survival in patients with brain metastases (BrMs).

Materials and methods: A retrospective analysis of patients with CNSms (BrMs or neoplastic meningitis) seen at two referral centers between 2010 and 2022. The neurological manifestations and their association with survival were measured and presented.

Results: Among 822 patients with CNSms, the most common neurological manifestations were headache, focal weakness, visual disorders, nausea/vomiting, seizures, and altered mental status (53%, 35%, 24%, 23%, 22%, and 18%, respectively). In patients with BrMs, neurological manifestations associated with survival were asymptomatic (hazard ratio [HR], 0.48 [95% CI, 0.31 to 0.73]; P = .001), focal weakness (HR, 1.26 [95% CI, 1.02 to 1.54]; P = .027), or visual disorders (HR, 1.26 [95% CI, 1.01 to 1.58]; P = .045).

Conclusion: Neurological manifestations in patients with BrMs are associated with survival and can aid in prognostic stratification.

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中枢神经系统转移患者的神经学表现：来自中高收入国家单一中心的经验。

目的：本研究旨在报道中枢神经系统转移（CNSm）患者的神经学表现，并确定其与脑转移（BrMs）患者生存的关系。材料和方法：回顾性分析2010年至2022年间在两个转诊中心就诊的CNSms （BrMs或肿瘤性脑膜炎）患者。测量并呈现神经学表现及其与生存的关系。结果：在822例CNSms患者中，最常见的神经学表现为头痛、局灶性无力、视觉障碍、恶心/呕吐、癫痫发作和精神状态改变（分别为53%、35%、24%、23%、22%和18%）。在BrMs患者中，与生存相关的神经系统表现为无症状(风险比[HR]， 0.48 [95% CI， 0.31至0.73]；P = .001)，焦点虚弱(HR, 1.26 [95% CI, 1.02 ~ 1.54]；P = 0.027)或视力障碍(HR, 1.26 [95% CI, 1.01 ~ 1.58]；P = .045)。结论：BrMs患者的神经学表现与生存有关，有助于预后分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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