Understanding epigenetic regulation in the endometrium - lessons from mouse models with implantation defects.

IF 3 4区医学 Q2 GENETICS & HEREDITY

Epigenomics Pub Date : 2025-06-01 Epub Date: 2025-04-14 DOI:10.1080/17501911.2025.2491298

Ryosuke Kobayashi, Izuho Hatada

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Abstract

Endometrial function, crucial for successful embryo implantation, is significantly influenced by epigenetic regulation. This review investigates the crucial roles of DNA methylation, histone modifications, chromatin remodeling, and RNA methylation in endometrial receptivity and implantation, based on a survey of recent literature on knockout mouse models with implantation defects. These models illuminate how epigenetic disruptions contribute to implantation failure, a significant human reproductive health concern. DNA methylation and histone modifications modulate endometrial receptivity by affecting gene silencing and chromatin structure, respectively. Chromatin remodeling factors also play a critical role in endometrial dynamics, influencing gene expression. Furthermore, RNA methylation emerges as critical in implantation through transcriptional and translational control. While human studies provide limited epigenetic snapshots, mouse models with suppressed epigenetic regulators reveal direct causal links between epigenetic alterations and implantation failure. Understanding these epigenetic interactions offers potential for novel therapies addressing reproductive disorders.

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了解子宫内膜的表观遗传调控——来自植入缺陷小鼠模型的经验教训。

子宫内膜功能是胚胎成功着床的关键，受表观遗传调控的显著影响。本文综述了DNA甲基化、组蛋白修饰、染色质重塑和RNA甲基化在子宫内膜容受性和着床中的重要作用，并对植入缺陷的敲除小鼠模型进行了综述。这些模型阐明了表观遗传破坏如何导致着床失败，这是一个重要的人类生殖健康问题。DNA甲基化和组蛋白修饰分别通过影响基因沉默和染色质结构来调节子宫内膜容受性。染色质重塑因子也在子宫内膜动力学中发挥关键作用，影响基因表达。此外，RNA甲基化通过转录和翻译控制在植入过程中发挥关键作用。虽然人类研究提供了有限的表观遗传快照，但抑制表观遗传调控因子的小鼠模型揭示了表观遗传改变与植入失败之间的直接因果关系。了解这些表观遗传相互作用为解决生殖疾病的新疗法提供了潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epigenomics GENETICS & HEREDITY-

CiteScore

5.80

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： Epigenomics provides the forum to address the rapidly progressing research developments in this ever-expanding field; to report on the major challenges ahead and critical advances that are propelling the science forward. The journal delivers this information in concise, at-a-glance article formats – invaluable to a time constrained community. Substantial developments in our current knowledge and understanding of genomics and epigenetics are constantly being made, yet this field is still in its infancy. Epigenomics provides a critical overview of the latest and most significant advances as they unfold and explores their potential application in the clinical setting.