Role of aspartate aminotransferase to platelet ratio in prediction of intrahepatic cholestasis of pregnancy.

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Experimental Hepatology Pub Date : 2024-12-01 Epub Date: 2024-12-02 DOI:10.5114/ceh.2024.145447

Nizamettin Bozbay, Şeyma Kılıç, Osman Yıldırım, Aybike Tazegül Pekin, Gökçen Örgül

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引用次数: 0

Abstract

Aim of the study: We aimed to compare the first, second and third trimester APRI (aspartate aminotransferase to platelet ratio index) scores in pregnant women with and without intrahepatic cholestasis (ICH).

Material and methods: In this study, 54 patients diagnosed with ICH and 59 healthy pregnant women admitted to a tertiary care center between 2018 and 2024 were evaluated. APRI scores were compared between the two groups for three trimesters (first, second, and third trimester). The optimal cut-off values of the APRI score for the prediction of ICH were analyzed.

Results: APRI scores were significantly higher in the ICH group in all trimesters (p = 0.028, p < 0.001, p < 0.001, respectively). The optimal cut-off value for APRI score to predict ICH in the first, second, and third trimesters was 0.06 (42.6% sensitivity, 83.1% specificity), 0.1 (57.4% sensitivity, 93.2% specificity) and 13 (77.8% sensitivity, 98.3% specificity), respectively.

Conclusions: APRI score was found to be a significant predictor of ICH throughout the entire pregnancy. APRI score seems to be a useful marker in clinical practice to predict ICH.

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天冬氨酸转氨酶与血小板比值在预测妊娠肝内胆汁淤积中的作用。

研究目的：我们的目的是比较有和没有肝内胆汁淤积（ICH）的孕妇在妊娠早期、中期和晚期的APRI（天冬氨酸转氨酶血小板比率指数）评分。材料与方法：本研究对2018年至2024年间在三级保健中心就诊的54例诊断为ICH的患者和59例健康孕妇进行评估。比较两组妊娠3个月（妊娠1、2、3个月）APRI评分。分析了APRI评分预测脑出血的最佳临界值。结果：ICH组APRI评分在各妊娠期均显著高于对照组（p = 0.028, p < 0.001, p < 0.001）。APRI评分预测妊娠早期、中期和晚期脑出血的最佳临界值分别为0.06（敏感性42.6%，特异性83.1%）、0.1（敏感性57.4%，特异性93.2%）和13（敏感性77.8%，特异性98.3%）。结论：APRI评分是整个妊娠期脑出血的重要预测指标。在临床实践中，APRI评分似乎是预测脑出血的有用指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： Clinical and Experimental Hepatology – quarterly of the Polish Association for Study of Liver – is a scientific and educational, peer-reviewed journal publishing original and review papers describing clinical and basic investigations in the field of hepatology.