Autonomic neuropathy is associated with an increase in type-1 cytokines in people living with HIV.

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Autonomic Research Pub Date : 2025-05-10 DOI:10.1007/s10286-025-01129-5

Bridget R Mueller, Mitali Mehta, Maya Campbell, Niyati Neupane, Gabriela Cedillo, Gina Lee, Kaitlyn Coyle, Jinging Qi, Zhihong Chen, Mary Catherine George, Jessica Robinson-Papp

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引用次数: 0

Abstract

Purpose: Pre-clinical studies have demonstrated direct influences of the autonomic nervous system (ANS) on the immune system. However, it remains unclear if ANS-immune connections delineated in these preclinical studies underlie the relationship between autonomic dysregulation and chronic inflammatory diseases in patients with human immunodeficiency virus (HIV). The aims of this study were: (1) to examine the relationship between interleukin-6 (IL-6) and the parasympathetic/vagal component of baroreflex sensitivity in people with HIV; (2) to determine whether the subtype and severity of HIV-autonomic neuropathy (AN) would predict distinct immunotypes; and (3) to compare the burden of non-acquired immunodeficiency syndrome (AIDS)-related co-morbidities between immunotypes.

Methods: A total of 79 adults with well-controlled HIV underwent a standard battery of autonomic function tests summarized as the Composite Autonomic Severity Score (CASS) and vagal and adrenergic baroreflex sensitivity (BRS-V and BRS-A, respectively) (Low: Mayo Clin Proc 68:748-752, 1993). Levels of immune biomarkers were measured in all participants using the Target 96 Inflammation Panel on the Olink proteomics platform, and immunotypes were identified using unbiased, non-negative matrix factorization. Mass cytometry (CyTOF) was completed on a subset of participants with and without autonomic neuropathy (N = 10).

Results: Reduced BRS-V predicted higher levels of IL-6 (p = 0.002). A pro-inflammatory immunotype defined by elevations in type 1 cytokines (IL-6, IL-17) and increased numbers of CD8+ T-cells was associated with autonomic neuropathy characterized by deficits in sympathetic nervous system activity (adjusted odds ratio 4.7, p = 0.017). This pro-inflammatory immunotype was older with a greater burden of co-morbidities.

Conclusion: Deficits in the parasympathetic/cardiovagal and the sympathetic nervous system are associated with inflammation and disease burden in people living with HIV. Future longitudinal research is needed to examine causality.

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在HIV感染者中，自主神经病变与1型细胞因子的增加有关。

目的：临床前研究已经证实了自主神经系统（ANS）对免疫系统的直接影响。然而，尚不清楚这些临床前研究中描述的ans -免疫联系是否构成了人类免疫缺陷病毒（HIV）患者自主神经失调与慢性炎症性疾病之间关系的基础。本研究的目的是：(1)研究白细胞介素-6 （IL-6）与HIV感染者压力反射敏感性副交感神经/迷走神经组分之间的关系；(2)确定hiv -自主神经病变（AN）的亚型和严重程度是否能预测不同的免疫类型；(3)比较不同免疫类型非获得性免疫缺陷综合征（AIDS）相关合并症的负担。方法：共有79名HIV控制良好的成年人接受了自主神经功能的标准测试，包括自主神经严重程度综合评分（CASS）和迷走神经和肾上腺素能压力反射敏感性（分别为BRS-V和BRS-A）（Low: Mayo clinic Proc 68:748-752, 1993）。使用Olink蛋白质组学平台上的Target 96炎症面板测量所有参与者的免疫生物标志物水平，并使用无偏、非阴性矩阵分解确定免疫类型。在有和没有自主神经病变的一部分参与者（N = 10）中完成了细胞计数（CyTOF）。结果：BRS-V降低预示着IL-6水平升高（p = 0.002）。由1型细胞因子（IL-6、IL-17）升高和CD8+ t细胞数量增加定义的促炎免疫型与以交感神经系统活性缺陷为特征的自主神经病变相关（校正优势比4.7,p = 0.017）。这种促炎免疫型患者年龄较大，合并症负担更大。结论：副交感/心血管和交感神经系统的缺陷与HIV感染者的炎症和疾病负担有关。未来的纵向研究需要检验因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Autonomic Research 医学-临床神经学

CiteScore

7.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Autonomic Research aims to draw together and disseminate research work from various disciplines and specialties dealing with clinical problems resulting from autonomic dysfunction. Areas to be covered include: cardiovascular system, neurology, diabetes, endocrinology, urology, pain disorders, ophthalmology, gastroenterology, toxicology and clinical pharmacology, skin infectious diseases, renal disease. This journal is an essential source of new information for everyone working in areas involving the autonomic nervous system. A major feature of Clinical Autonomic Research is its speed of publication coupled with the highest refereeing standards.