An Effective and Safe Laser Treatment Strategy of Fractional Carbon Dioxide Laser for Chinese Populations with Periorbital Wrinkles: A Randomized Split-Face Trial.

IF 3.5 3区医学 Q1 DERMATOLOGY

Dermatology and Therapy Pub Date : 2025-06-01 Epub Date: 2025-04-12 DOI:10.1007/s13555-025-01404-3

Xianglei Wu, Qingqing Cen, Jian Jin, Wei Gao, Ying Shang, Linting Huang, Xiaoxi Lin

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引用次数: 0

Abstract

Introduction: Ablative carbon dioxide fractional laser (CO₂ AFL) can alleviate static wrinkles; however, its use in East Asian populations can predispose them to postinflammatory hyperpigmentation (PIH). We aimed to explore the optimum energy and coverage parameters of CO₂ AFL for treating static periorbital wrinkles in a Chinese population and to minimize PIH incidence.

Methods: In total, 30 patients with static periorbital wrinkles were recruited. The PIH intervention side (1% hydroquinone cream every night on one periorbital area for each patient 1 month before and from the 8th day to 1 month after each treatment) and group (group A: 15‒20 mJ, 5%; group B: 10‒12.5 mJ, 15%; and group C: 12.5‒15 mJ, 10%) were determined randomly. The patients underwent two sessions of CO₂ AFL at 3-month intervals. Follow-ups were conducted until 6 months after the last treatment.

Results: Overall, 20 participants (48.1 ± 13.1 years) completed all follow-ups without any serious complications. The application of hydroquinone significantly reduced PIH (p = 0.02). Both the investigators' and patients' visual evaluations demonstrated a consistent efficacy rate of 68.2% without differences between groups. The Fitzpatrick wrinkle score significantly decreased compared with pre-treatment (p < 0.01); however, a significant reduction only in group B at 3 months (p = 0.016) and 6 months (p = 0.001) post-treatment was observed. Groups B and C demonstrated significant reductions in superficial and deep wrinkles and pigmentation (p < 0.01).

Conclusions: CO₂ AFL effectively reduced static periorbital wrinkles in the Chinese population. Low energy combined with high-density coverage was the most efficacious. The application of hydroquinone significantly reduced PIH incidence.

Trial registration: Chinese Clinical Trial Registration no. ChiCTR2400087320 (date of trial registration: 25 July 2024).

查看原文本刊更多论文

一种有效、安全的二氧化碳激光治疗中国眼窝周围皱纹的方法：一项随机裂面试验。

导读：烧蚀二氧化碳分数激光（CO2 AFL）可以缓解静态皱纹；然而，在东亚人群中使用它会使他们易患炎症后色素沉着（PIH）。我们的目的是探索CO2 AFL治疗中国人群静态眶周皱纹的最佳能量和覆盖参数，并最大限度地减少PIH的发生率。方法：共招募30例静态眶周皱纹患者。PIH干预组（每次治疗前1个月及治疗后第8天至1个月，每位患者每晚在一个眶周涂抹1%对苯二酚乳膏）和组(A组：15-20 mJ， 5%；B组：10-12.5 mJ, 15%；C组：12.5 ~ 15 mJ, 10%)随机选取。患者每隔3个月接受两次CO2 AFL治疗。随访至末次治疗后6个月。结果：20例患者（48.1±13.1岁）完成随访，无严重并发症。对苯二酚可显著降低PIH （p = 0.02）。研究者和患者的视觉评价均显示出一致的有效率为68.2%，组间无差异。与治疗前相比，Fitzpatrick皱纹评分显著降低(p)。结论：CO2 AFL有效地减少了中国人群的静态眶周皱纹。低能量与高密度覆盖相结合是最有效的。对苯二酚的应用显著降低了PIH的发病率。试验注册：中国临床试验注册号：ChiCTR2400087320（试验注册日期：2024年7月25日）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatology and Therapy Medicine-Dermatology

CiteScore

6.00

自引率

8.80%

发文量

187

审稿时长

6 weeks

期刊介绍： Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.