More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors.

Abstract

Objective: The circadian rhythm synchronizes physiological and behavioral patterns with the 24-h light-dark cycle. Disruption to the circadian rhythm is linked to various health conditions, although optimal methods to describe these disruptions remain unclear. An emerging approach is to examine the intraindividual variability in measurable properties of the circadian rhythm over extended periods. Epileptic seizures are modulated by circadian rhythms, but the relevance of circadian rhythm disruption in epilepsy remains unexplored. Our study investigates intraindividual circadian variability in epilepsy and its relationship with seizures.

Methods: We retrospectively analyzed >70 000 h of wearable smartwatch data (Fitbit) from 143 people with epilepsy (PWE) and 31 healthy controls. Circadian oscillations in heart rate time series were extracted, daily estimates of circadian period, acrophase, and amplitude properties were produced, and estimates of the intraindividual variability of these properties over an entire recording were calculated.

Results: PWE exhibited greater intraindividual variability in period (76 vs. 57 min, d = .66, p < .001) and acrophase (64 vs. 48 min, d = .49, p = .004) compared to controls, but not in amplitude (2 beats per minute, d = -.15, p = .49). Variability in circadian properties showed no correlation with seizure frequency nor any differences between weeks with and without seizures.

Significance: For the first time, we show that heart rate circadian rhythms are more variable in PWE, detectable via consumer wearable devices. However, no association with seizure frequency or occurrence was found, suggesting that this variability might be underpinned by the epilepsy etiology rather than being a seizure-driven effect.