Pilot study of a novel resection extent determination method using bone single-photon emission computed tomography-standardized uptake value in medication-related osteonecrosis of the jaw.

IF 2.9 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Dento maxillo facial radiology Pub Date : 2025-04-15 DOI:10.1093/dmfr/twaf032

Naoya Hayashi, Norikazu Matsutomo, Ryotaro Tokorodani, Mitsuha Fukami, Miki Nishimori, Kie Nakatani, Yukio Yoshioka, Yoshihiro Hayashi, Ichiro Murakami, Takuji Yamagami, Tetsuya Yamamoto, Tomoaki Yamamoto

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引用次数: 0

Abstract

Objective: Surgery is the standard treatment for medication-related osteonecrosis of the jaw (MRONJ). However, there are few reports on the appropriate extent of the bone resection. This pilot study explores the feasibility of a new method for estimating the extent of resection using bone single-photon emission computed tomography (SPECT)-standardized uptake value (SUV).

Methods: We retrospectively analyzed 8 MRONJ patients who underwent curettage (n = 2), curettage with removal of the separated sequestrum (n = 2), or marginal resection (n = 4) as part of extensive surgery. The resected regions were compared with the regions estimated using SPECT-SUV. The agreement between the SPECT cold region and the resected region was evaluated using the Dice coefficient (defined as the ratio of 2 × overlap volume to resected volume plus SPECT cold region volume), overlap ratio, and volume ratio. The inclusion of CT findings (osteolytic, gap- and irregular-type periosteal reactions, and mixed-type osteosclerosis) in the estimated region was also evaluated. Additionally, histopathological findings from 3 marginal resection cases were used to validate the estimated region.

Results: In all cases, the resected region included the cold regions observed on bone SPECT, with radiotracer accumulation confirmed around the resected region. CT-osteolytic regions were included within the estimated region. The Dice coefficient was 0.53 ± 0.10, the overlap ratio was 86.7 ± 7.2%, and the volume ratio was 235.0 ± 74.7%. Histopathological analysis revealed significant osteocyte necrosis in cold regions, whereas areas with an SUV of 9 displayed normal osteocytes, newly formed bone, and mild inflammatory cell infiltration.

Conclusion: This study suggests that the setting of the SPECT-cold region using bone SPECT-SUV may allow for the estimation of the extent of resection in early-to-intermediate-stage MRONJ.

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使用骨单光子发射计算机断层扫描标准化摄取值测定颌骨药物相关性骨坏死切除范围的新方法的初步研究。

目的：手术是治疗药物相关性颌骨骨坏死（MRONJ）的标准方法。然而，关于骨切除的适当范围的报道很少。本初步研究探讨了一种利用骨单光子发射计算机断层扫描(SPECT)-标准化摄取值（SUV）估计切除程度的新方法的可行性。方法：我们回顾性分析了8例MRONJ患者，这些患者分别接受了刮除术（n = 2）、刮除分离残体（n = 2）或边缘切除术（n = 4）作为广泛手术的一部分。将切除的区域与SPECT-SUV估计的区域进行比较。使用Dice系数（定义为重叠体积与切除体积加上SPECT冷区体积的2倍之比）、重叠比和体积比来评估SPECT冷区与切除区域之间的一致性。CT检查结果（溶骨性、间隙性和不规则型骨膜反应以及混合型骨硬化）在估计区域也被评估。此外，3例边缘切除病例的组织病理学结果被用来验证估计的区域。结果：在所有病例中，切除区域包括骨SPECT观察到的冷区，在切除区域周围证实有放射性示踪剂积累。ct溶骨区域包括在估计区域内。Dice系数为0.53±0.10，重叠比为86.7±7.2%，体积比为235.0±74.7%。组织病理学分析显示，寒冷地区明显的骨细胞坏死，而SUV为9的地区显示正常骨细胞，新形成的骨和轻度炎症细胞浸润。结论：本研究表明，使用骨SPECT-SUV设置spect -冷区可能允许估计早期至中期MRONJ的切除程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dento maxillo facial radiology 医学-核医学

CiteScore

5.60

自引率

9.10%

发文量

审稿时长

4-8 weeks

期刊介绍： Dentomaxillofacial Radiology (DMFR) is the journal of the International Association of Dentomaxillofacial Radiology (IADMFR) and covers the closely related fields of oral radiology and head and neck imaging. Established in 1972, DMFR is a key resource keeping dentists, radiologists and clinicians and scientists with an interest in Head and Neck imaging abreast of important research and developments in oral and maxillofacial radiology. The DMFR editorial board features a panel of international experts including Editor-in-Chief Professor Ralf Schulze. Our editorial board provide their expertise and guidance in shaping the content and direction of the journal. Quick Facts: - 2015 Impact Factor - 1.919 - Receipt to first decision - average of 3 weeks - Acceptance to online publication - average of 3 weeks - Open access option - ISSN: 0250-832X - eISSN: 1476-542X