Akpome Akan, Lawrence Omo-Aghoja, Ayotunde Adeyinka
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引用次数: 0
Abstract
Background: Incidence of cervical cancer can be reduced using screening tests such as Pap smear to detect the premalignant stage of the disease. Although there has been a preference for more expensive human papillomavirus DNA testing due to its higher sensitivity, the Pap smear remains still very relevant in low-resource settings being cheaper and more readily available, hence the need to study factors influencing its performance.
Objective: The objective of this study was to determine if there is a difference in the diagnostic performance of Pap smear performed during the proliferative and secretory phases of a menstrual cycle, using colposcopy as the gold standard.
Materials and methods: It was a community-based, comparative cross-sectional study conducted in Oghara, in Ethiope West Local Government Area, Delta State, Nigeria, over a 32-week period from January to July 2020. The participants had an integrated four-step procedure comprising Pap smear sample collection and colposcopy assessment performed during the proliferative and secretory phases of their menstrual cycle. Consenting participants who had an abnormal colposcopy finding during either phase of the cycle had cervical biopsy sampling.
Results: There was no significant difference in the sensitivities (0.00 vs. 0.00), specificities (99.04 vs. 97.14, P = 0.300), positive predictive values (0.00 vs. 0.00), negative predictive values (93.63 vs. 94.44, P = 0.672) and accuracies (92.80 vs. 91.60, P = 0.317) of Pap smears performed at proliferative and secretory phases of menstrual cycle.
Conclusion: Pap smear can be collected during either phase of a woman's menstrual cycle.
背景:使用巴氏涂片检查等筛检方法,可减低子宫颈癌的发病率。尽管由于其更高的灵敏度,人们倾向于更昂贵的人乳头瘤病毒DNA检测,但巴氏涂片检查在资源匮乏的环境中仍然非常重要,因为它更便宜,更容易获得,因此需要研究影响其性能的因素。目的:本研究的目的是确定在月经周期的增殖期和分泌期进行巴氏涂片检查的诊断性能是否存在差异,以阴道镜检查为金标准。材料和方法:这是一项基于社区的比较横断面研究,于2020年1月至7月在尼日利亚三角洲州埃塞俄比亚西部地方政府区Oghara进行,为期32周。参与者在月经周期的增殖和分泌阶段进行了包括子宫颈抹片样本收集和阴道镜评估在内的综合四步程序。同意的参与者在周期的任何阶段有异常阴道镜检查发现宫颈活检取样。结果:宫颈抹片检查在月经周期增殖期和分泌期的敏感性(0.00 vs. 0.00)、特异性(99.04 vs. 97.14, P = 0.300)、阳性预测值(0.00 vs. 0.00)、阴性预测值(93.63 vs. 94.44, P = 0.672)和准确性(92.80 vs. 91.60, P = 0.317)差异无统计学意义。结论:宫颈抹片检查可在女性月经周期的任何阶段进行。