{"title":"Myotubularin related protein 7, a novel STIM1 binding protein.","authors":"Ning Dai, Jody Groenendyk, Marek Michalak","doi":"10.1139/cjpp-2025-0039","DOIUrl":null,"url":null,"abstract":"<p><p>Stromal interaction molecule 1 (STIM1) is a Ca<sup>2+</sup> sensor in the endoplasmic reticulum (ER) membrane. The protein plays a crucial role in store-operated Ca<sup>2+</sup> entry (SOCE) by transducing ER Ca<sup>2+</sup> depletion signals to Ca<sup>2+</sup> release-activated Ca<sup>2+</sup> channel protein 1 (ORAI1) at the plasma membrane. Myotubularin related protein 7 (MTMR7) is a lipid phosphatase that dephosphorylates phosphoinositides. Using yeast two-hybrid analysis, immunoprecipitation and fluorescence microscopy, we discovered that MTMR7 interacts with STIM1 at the ER. These observations identified MTMR7 as a novel STIM1-binding protein that bridges myotubularins and phosphoinositide signaling with SOCE. Our research revealed a novel link between Ca<sup>2+</sup> signaling and phosphoinositide biology, positioning MTMR7 as a potential marker or drug target for SOCE related human pathophysiology.</p>","PeriodicalId":9520,"journal":{"name":"Canadian journal of physiology and pharmacology","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of physiology and pharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1139/cjpp-2025-0039","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Stromal interaction molecule 1 (STIM1) is a Ca2+ sensor in the endoplasmic reticulum (ER) membrane. The protein plays a crucial role in store-operated Ca2+ entry (SOCE) by transducing ER Ca2+ depletion signals to Ca2+ release-activated Ca2+ channel protein 1 (ORAI1) at the plasma membrane. Myotubularin related protein 7 (MTMR7) is a lipid phosphatase that dephosphorylates phosphoinositides. Using yeast two-hybrid analysis, immunoprecipitation and fluorescence microscopy, we discovered that MTMR7 interacts with STIM1 at the ER. These observations identified MTMR7 as a novel STIM1-binding protein that bridges myotubularins and phosphoinositide signaling with SOCE. Our research revealed a novel link between Ca2+ signaling and phosphoinositide biology, positioning MTMR7 as a potential marker or drug target for SOCE related human pathophysiology.
期刊介绍：
Published since 1929, the Canadian Journal of Physiology and Pharmacology is a monthly journal that reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership. The journal periodically publishes a “Made In Canada” special section that features invited review articles from internationally recognized scientists who have received some of their training in Canada.
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