Glomerular filtration rate and sexual dimorphism: lessons from animal and human studies.

IF 2.2 3区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Elise Bouderlique, Romain Pszczolinski, Caroline Prot-Bertoye, Marie Courbebaisse
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引用次数: 0

Abstract

Purpose of review: Integrating sex-based analyses is becoming a key point in the new recommendations, particularly in nephrology.

Recent findings: Whereas single nephron glomerular filtration rate (GFR) is not different between men and women, male sex is associated, after multiple adjustments, with a higher number of nephrons. However, after indexation to body surface area, measured GFR (mGFR) in healthy potential kidney donors is not different between men and women between 20 and 50 years of age. After 50 years, mGFR decline seems faster in women than in men, which is concordant with the protective role of estrogens on renal function, as demonstrated in animal and some human studies. Conversely, testosterone has a detrimental effect on renal function. Of note, although testosterone has been shown to increase the kidney volume of the remnant kidney after a unilateral nephrectomy in animal models, this may generate deleterious hyperfiltration in the longer term.

Summary: Taken together, these data highlight the impact of sex on GFR, notably through sexual hormones whose receptors are expressed in glomerular cells.

肾小球滤过率和两性异形:来自动物和人类研究的经验教训。
综述目的:整合基于性别的分析正在成为新建议的一个关键点,特别是在肾脏病学方面。最近的研究发现:尽管单肾单位肾小球滤过率(GFR)在男性和女性之间没有差异,但在多次调整后,男性与较高数量的肾单位有关。然而,在以体表面积为指标后,健康潜在肾脏供者的GFR (mGFR)在20至50岁的男性和女性之间没有差异。50年后,女性的mGFR下降速度似乎比男性快,这与动物和一些人体研究证明的雌激素对肾功能的保护作用是一致的。相反,睾酮对肾功能有不利影响。值得注意的是,尽管在动物模型中睾酮已被证明会增加单侧肾切除术后残余肾的体积,但从长远来看,这可能会产生有害的超滤。总结:综上所述,这些数据强调了性别对GFR的影响,特别是通过肾小球细胞中表达的性激素受体。
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来源期刊
Current Opinion in Nephrology and Hypertension
Current Opinion in Nephrology and Hypertension 医学-泌尿学与肾脏学
CiteScore
5.70
自引率
6.20%
发文量
132
审稿时长
6-12 weeks
期刊介绍: A reader-friendly resource, Current Opinion in Nephrology and Hypertension provides an up-to-date account of the most important advances in the field of nephrology and hypertension. Each issue contains either two or three sections delivering a diverse and comprehensive coverage of all the key issues, including pathophysiology of hypertension, circulation and hemodynamics, and clinical nephrology. Current Opinion in Nephrology and Hypertension is an indispensable journal for the busy clinician, researcher or student.
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