Characteristics of comparatively young heart failure with preserved ejection fraction: PurSuit-HFpEF registry.

IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Heart and Vessels Pub Date : 2025-10-01 Epub Date: 2025-04-15 DOI:10.1007/s00380-025-02545-3
Masami Nishino, Yasuyuki Egami, Ayako Sugino, Noriyuki Kobayashi, Masaru Abe, Mizuki Ohsuga, Hiroaki Nohara, Shodai Kawanami, Kohei Ukita, Akito Kawamura, Koji Yasumoto, Naotaka Okamoto, Yasuharu Matsunaga-Lee, Masamichi Yano, Takahisa Yamada, Yoshio Yasumura, Masahiro Seo, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Shunsuke Tamaki, Katsuki Okada, Yohei Sotomi, Daisaku Nakatani, Shungo Hikoso, Yasushi Sakata
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引用次数: 0

Abstract

Because heart failure (HF) with preserved ejection fraction (HFpEF) is mainly a disease of elderly, there are a few reports focusing young patients. This study aims to elucidate characteristics of comparatively young HFpEF patients. We divided HFpEF patients in PURSUIT-HFpEF registry into younger HFpEF group (age ≤ 65 years) and older HFpEF group and compared the all-cause mortality and HF readmission (HFR) between the two groups and identified discharge factors correlated with HFR among younger HFpEF patients. The younger HFpEF group comprised 51 patients (4.1%). In this group, body mass index and smoking were significantly higher, while hypertension was significantly lower compared to older HFpEF group. Kaplan-Meier analysis indicated no significant difference in HFR between the groups, although all-cause mortality was significantly lower in younger HFpEF group (p < 0.001). Multivariable Cox proportional hazards analysis indicated that angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) were inversely correlated with HFR, whereas mineralocorticoid receptor antagonists (MRA) were positively correlated with HFR in younger HFpEF patients (p = 0.004 and p = 0.007, respectively). In conclusion, younger HFpEF is rare (approximately 4%), with obesity and smoking being significant modifiable factors. HFR was similar between younger and older HFpEF patients. Administration of ACEI/ARB and unnecessity of MRA at discharge may be associated with reducing HFR in younger HFpEF patients.

保存射血分数的相对年轻心力衰竭的特征:追踪- hfpef登记。
由于保留射血分数的心力衰竭(HF)主要是老年人的疾病,很少有关于年轻患者的报道。本研究旨在阐明相对年轻的HFpEF患者的特点。我们将追踪的HFpEF患者分为年龄≤65岁的年轻HFpEF组和年龄较大的HFpEF组,比较两组患者的全因死亡率和HF再入院(HFR),并确定年轻HFpEF患者中与HFR相关的出院因素。年轻的HFpEF组有51例(4.1%)。与老年HFpEF组相比,该组的体重指数和吸烟明显较高,而高血压明显较低。Kaplan-Meier分析显示,两组间HFR无显著差异,尽管年轻HFpEF组的全因死亡率明显较低(p
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来源期刊
Heart and Vessels
Heart and Vessels 医学-外周血管病
CiteScore
3.10
自引率
13.30%
发文量
211
审稿时长
2 months
期刊介绍: Heart and Vessels is an English-language journal that provides a forum of original ideas, excellent methods, and fascinating techniques on cardiovascular disease fields. All papers submitted for publication are evaluated only with regard to scientific quality and relevance to the heart and vessels. Contributions from those engaged in practical medicine, as well as from those involved in basic research, are welcomed.
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