Bariatric surgery promotes recruitment of brown fat linked to alterations in the gut microbiota.

IF 5.3 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

European Journal of Endocrinology Pub Date : 2025-04-30 DOI:10.1093/ejendo/lvaf081

Carsten T Herz, Oana C Kulterer, Marlene Prager, Rodrig Marculescu, Gerhard Prager, Alexandra Kautzky-Willer, Marcus Hacker, Slave Trajanoski, Harald C Köfeler, Birgit Gallé, Alexander R Haug, David Berry, Florian W Kiefer

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引用次数: 0

Abstract

Objective: The mechanisms of bariatric surgery-induced weight loss and metabolic improvements are still incompletely understood and reach beyond malabsorption or calorie restriction. We sought to investigate the effect of bariatric surgery on brown adipose tissue (BAT) activity and a potential connection with changes in energy metabolism, the gut microbiota, and short-chain fatty acid (SCFA) composition.

Methods: We included 32 subjects (25 females) with morbid obesity and analyzed their metabolic profile, gut microbiota composition, circulating SCFAs, energy expenditure, and cold-induced BAT activity using [18F]Fluorodeoxyglucose-positron emission tomography-computed tomography before and up to 1 year after bariatric surgery.

Results: Twelve months after surgery, the percentage of individuals with active BAT had increased from 28% to 53%. The BAT-negative (BATneg) individuals who had an adverse metabolic profile at baseline compared with subjects with active BAT (BATpos) showed a greater metabolic benefit after surgery. While no changes in overall gut bacterial diversity were observed between BATpos and BATneg, the abundance of 3 specific bacterial families, including Akkermansiaceae, Pasteurellaceae, and Carnobacteriaceae, was distinctly regulated between BAT groups. The bacterial genera most strongly increased in BATpos vs BATneg subjects were all positively correlated with BAT volume and BAT activity. Finally, circulating concentrations of the SCFAs acetate, butyrate, and propionate rose after bariatric surgery and were related to bacterial genera such as Akkermansia, Dialister, and Lachnospiraceae FCS020 group, all known SCFA producers.

Conclusions: Bariatric surgery helps recruit active BAT in individuals with obesity and is linked to distinct alterations in the gut microbiome and SCFA composition.

Trial registration number: ClinicalTrials.gov (NCT03168009).

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减肥手术促进了与肠道微生物群改变有关的棕色脂肪的补充。

目的：减肥手术引起的体重减轻和代谢改善的机制仍然不完全清楚，并且超出了吸收不良或热量限制。我们试图研究减肥手术对棕色脂肪组织（BAT）活性的影响，以及与能量代谢、肠道微生物群和短链脂肪酸（SCFA）组成变化的潜在联系。方法：我们纳入了32名患有病态肥胖的受试者（25名女性），并在减肥手术前和手术后1年内使用[18F]氟脱氧葡萄糖-正电子发射断层扫描-计算机断层扫描分析了他们的代谢谱、肠道微生物群组成、循环scfa、能量消耗和冷诱导BAT活性。结果：术后12个月，活跃BAT的个体百分比从28%增加到53%。与具有活性BAT （BATpos）的受试者相比，在基线时具有不良代谢特征的BAT阴性（BATneg）个体在手术后显示出更大的代谢益处。虽然BATpos组和BATneg组的肠道细菌多样性总体上没有变化，但3个特定细菌科（Akkermansiaceae, Pasteurellaceae, carnobacteraceae）的丰度在BAT组之间明显受到调节。在BATpos组和batnegg组中增加最多的细菌属均与BAT体积和BAT活性呈正相关。最后，减肥手术后循环中SCFA的乙酸、丁酸和丙酸浓度上升，并且与Akkermansia、Dialister和Lachnospiraceae FCS020群等细菌属有关，这些细菌属都是已知的SCFA产生菌。结论：减肥手术有助于在肥胖患者中招募活跃的BAT，并与肠道微生物组和SCFA组成的明显改变有关。试验注册号：ClinicalTrials.gov （NCT03168009）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Endocrinology 医学-内分泌学与代谢

CiteScore

9.80

自引率

3.40%

发文量

354

审稿时长

1 months

期刊介绍： European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.