[Renal Lipid Metabolism in Collagenopathies].

Abstract

Starting from the old concept of "fatty degeneration of the kidney", numerous studies have investigated lipid metabolism in chronic kidney disease. Today, it is known that collagenopathies, and more generally diseases involving alterations of the glomerular basement membrane, are characterized by intrapodocyte accumulation of lipid droplets, independent of serum cholesterol levels. Consequently, the latest scientific evidence has focused on the link between the kidney and lipid droplets, ubiquitous but unique organelles, at the same time allies and enemies of renal cells.