High-amylose starch forms complexes with bioactive compounds present in the Amphipterygium adstringent ethanol extract.

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Journal of pharmaceutical sciences Pub Date : 2025-05-10 DOI:10.1016/j.xphs.2025.103824

Luis A Bello-Perez, Edith Agama-Acevedo, Josue Moreno-Zaragoza, Perla Osorio-Diaz, Daniel Arrieta-Baez

{"title":"High-amylose starch forms complexes with bioactive compounds present in the Amphipterygium adstringent ethanol extract.","authors":"Luis A Bello-Perez, Edith Agama-Acevedo, Josue Moreno-Zaragoza, Perla Osorio-Diaz, Daniel Arrieta-Baez","doi":"10.1016/j.xphs.2025.103824","DOIUrl":null,"url":null,"abstract":"<p><p>Plants have been used for thousands of years to treat health problems. The bioactive compounds in parts of them are associated with cures for some diseases. The protection and release of bioactive compounds (bioaccessibility) are key issues in producing a therapeutic effect. Amylose and amylopectin, starch macromolecules, produce interactions with bioactive compounds, resulting in the formation of complexes. This study aimed to analyze the bioactive compounds in the complex produced between Amphipterygium adstringens (AA, cuachalalate) extract and high-amylose starch. Both the extract and the complex were analyzed by ultra-high-resolution liquid chromatography. AA extract showed compounds associated with antioxidant, anti-inflammatory, antibiotic, and anti-tumoral effects. The complex showed reduced compounds in the extract, and some compounds were not complexed with starch. The bioactive compounds present in the extract of medicinal plants can be complexed with amylose for their protection when ingested orally.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":" ","pages":"103824"},"PeriodicalIF":3.7000,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmaceutical sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.xphs.2025.103824","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Plants have been used for thousands of years to treat health problems. The bioactive compounds in parts of them are associated with cures for some diseases. The protection and release of bioactive compounds (bioaccessibility) are key issues in producing a therapeutic effect. Amylose and amylopectin, starch macromolecules, produce interactions with bioactive compounds, resulting in the formation of complexes. This study aimed to analyze the bioactive compounds in the complex produced between Amphipterygium adstringens (AA, cuachalalate) extract and high-amylose starch. Both the extract and the complex were analyzed by ultra-high-resolution liquid chromatography. AA extract showed compounds associated with antioxidant, anti-inflammatory, antibiotic, and anti-tumoral effects. The complex showed reduced compounds in the extract, and some compounds were not complexed with starch. The bioactive compounds present in the extract of medicinal plants can be complexed with amylose for their protection when ingested orally.

查看原文本刊更多论文

高直链淀粉形成复合物与生物活性化合物存在于翼翼状胬肉乙醇提取物。

几千年来，植物一直被用来治疗健康问题。其中部分的生物活性化合物与某些疾病的治疗有关。生物活性化合物的保护和释放（生物可及性）是产生治疗效果的关键问题。淀粉大分子直链淀粉和支链淀粉与生物活性化合物相互作用，形成复合物。本研究旨在分析双翅胬肉（AA, cuachalalate）提取物与高直链淀粉复合物的生物活性成分。采用超高分辨率液相色谱法对提取物和配合物进行分析。AA提取物具有抗氧化、抗炎、抗菌和抗肿瘤作用。该配合物在提取物中显示出减少的化合物，并且一些化合物不与淀粉配合。药用植物提取物中存在的生物活性化合物可与直链淀粉络合，以在口服时提供保护。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of pharmaceutical sciences 医学-化学综合

CiteScore

7.30

自引率

13.20%

发文量

367

审稿时长

33 days

期刊介绍： The Journal of Pharmaceutical Sciences will publish original research papers, original research notes, invited topical reviews (including Minireviews), and editorial commentary and news. The area of focus shall be concepts in basic pharmaceutical science and such topics as chemical processing of pharmaceuticals, including crystallization, lyophilization, chemical stability of drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology, and targeted drug delivery.