Triglyceride glucose waist circumference and non alcoholic fatty liver disease: a systematic review and meta analysis.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMC Gastroenterology Pub Date : 2025-05-01 DOI:10.1186/s12876-025-03888-x

Ziyi Xin, Lanlan Feng, Qingwen Yu, Yongmin Shi, Ting Tang, Xuhan Tong, Siqi Hu, Yao You, Shenghui Zhang, Xingwei Zhang, Mingwei Wang, Jiake Tang

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Abstract

Background: Insulin resistance (IR) plays a noticeable role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The triglyceride glucose-waist circumference (TyG-WC) index, a novel measure for assessing IR, may hold significant predictive value for NAFLD. However, the relationship between TyG-WC and the risk of NAFLD remains elusive. To investigate this association, this comprehensive meta-analysis was conducted.

Methods: A systematic electronic search was conducted using the PubMed, Embase, and Web of Science databases from their inception until July 2024 to identify observational studies assessing the relationship between TyG-WC and the risk of NAFLD. Joanna Briggs Institute's critical appraisal checklist was utilized to evaluate the quality of cross-sectional studies, while the Newcastle-Ottawa Scale (NOS) score was used to assess cohort studies. The principal summary outcomes included the mean difference (MD) and the corresponding 95% confidence interval (CI).

Results: In total, 10 studies comprising 38,518 participants were included in this meta-analysis, of whom 37% were diagnosed with NAFLD. The analysis revealed a significant MD between NAFLD and non-NAFLD cases (MD, 137.41; [95% CI, 121.52-153.31]).

Conclusion: A significant MD was identified between NAFLD and non-NAFLD cases. The TyG-WC index was found to be positively correlated with the risk of NAFLD, suggesting that it may serve as a potential indicator for NAFLD.

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甘油三酯葡萄糖腰围与非酒精性脂肪肝：一项系统综述和meta分析。

背景：胰岛素抵抗（IR）在非酒精性脂肪性肝病（NAFLD）的发病机制中起着重要作用。甘油三酯葡萄糖腰围（TyG-WC）指数是一种评估IR的新指标，可能对NAFLD具有重要的预测价值。然而，TyG-WC与NAFLD风险之间的关系仍然难以捉摸。为了调查这种关联，我们进行了全面的荟萃分析。方法：从PubMed、Embase和Web of Science数据库建立到2024年7月进行系统的电子检索，以确定评估TyG-WC与NAFLD风险之间关系的观察性研究。乔安娜布里格斯研究所的关键评估清单用于评估横断面研究的质量，而纽卡斯尔-渥太华量表（NOS）评分用于评估队列研究。主要总结结果包括平均差（MD）和相应的95%置信区间（CI）。结果：本荟萃分析共纳入10项研究，包括38,518名参与者，其中37%被诊断为NAFLD。分析显示，NAFLD与非NAFLD之间存在显著的MD (MD, 137.41；[95% ci, 121.52-153.31])。结论：NAFLD与非NAFLD之间存在明显的MD差异。TyG-WC指数与NAFLD风险呈正相关，提示其可作为NAFLD的潜在指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.