Incidence of sudden unexpected death in epilepsy in New Zealand: A prospective population-wide, 2-year study.

IF 6.6 1区医学 Q1 CLINICAL NEUROLOGY

Epilepsia Pub Date : 2025-05-12 DOI:10.1111/epi.18452

Peter S Bergin, Sunayana Sasikumar, Erica Beilharz, Charley Glenn, Robert Scragg

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引用次数: 0

Abstract

Objective: This study was undertaken to determine the incidence of sudden unexpected death in epilepsy (SUDEP) in New Zealand.

Methods: We attempted to prospectively identify all people with epilepsy (PWE) in New Zealand who died from SUDEP after August 1, 2019. Information about the patients' death and epilepsy was recorded in the EpiNet database. Two neurologists (P.S.B. and S.S.) reviewed each case and determined the SUDEP category. The national censuses for 2018 and 2023 were used as the denominator population.

Results: Records for 440 PWE who died between August 1, 2019 and July 31, 2021 were reviewed. We concluded that 103 people died from definite, definite plus, probable, probable plus, or resuscitated SUDEP (hereafter referred to as SUDEP). Possible SUDEP was diagnosed in 54. The crude incidence of SUDEP was 10.7 (95% confidence interval [CI] = 8.7-12.9)/1 million person-years. If the prevalence of active epilepsy in New Zealand was 5.49/1000 people, then the incidence of SUDEP in PWE was 1.93 (95% CI = 1.46-2.55) per 1000 person-years. If possible cases are included, the crude incidence of SUDEP was 16.2 (95% CI = 13.8-18.9) per 1 million person-years, and in PWE was 2.94 (95% CI = 2.23-3.89) per 1000 person-years. Sixty-five patients were male, and 38 were female (incidence rate ratio [IRR] = 1.75, 95% CI = 1.18-2.63, p = .005). The rate of SUDEP was lower among Asian people living in New Zealand compared with New Zealand European people (IRR = .33, 95% CI = .10-.83, p = .015). There was a trend toward a higher incidence in Māori and Pacific peoples. Employment status was known for 62 people, of whom 23 were unemployed.

Significance: The incidence of SUDEP in New Zealand in PWE (1.93/1000 person-years) is higher than usually reported for high-income countries, although there is uncertainty regarding the prevalence of epilepsy in New Zealand. We suspect the actual incidence of SUDEP worldwide is higher than is usually reported.

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新西兰癫痫患者猝死的发生率：一项为期2年的前瞻性人群研究

目的：本研究旨在确定新西兰癫痫猝死（SUDEP）的发生率。方法：我们试图前瞻性地识别2019年8月1日之后死于SUDEP的新西兰所有癫痫患者（PWE）。有关患者死亡和癫痫的信息记录在EpiNet数据库中。两名神经科医生（P.S.B.和S.S.）审查了每个病例并确定了SUDEP的类别。以2018年和2023年全国人口普查为分母人口。结果：回顾了2019年8月1日至2021年7月31日期间死亡的440例PWE的记录。我们的结论是103人死于明确的、明确的、可能的、可能的和复苏的SUDEP（以下简称SUDEP）。54例诊断为可能的猝死。SUDEP的粗发生率为10.7(95%可信区间[CI] = 8.7-12.9)/ 100万人年。如果新西兰的活动性癫痫患病率为5.49/1000人，那么PWE的SUDEP发病率为1.93 /1000人年（95% CI = 1.46-2.55）。如果包括可能的病例，SUDEP的粗发病率为16.2 (95% CI = 13.8-18.9) / 100万人年，PWE为2.94 (95% CI = 2.23-3.89) / 1000人年。男性65例，女性38例（发病率比[IRR] = 1.75, 95% CI = 1.18-2.63, p = 0.005）。与新西兰的欧洲人相比，居住在新西兰的亚洲人患SUDEP的比例较低(IRR =。33, 95% ci = 0.10 -。83, p = .015)。在Māori和太平洋地区有较高发病率的趋势。就业状况为62人，其中23人失业。意义：新西兰PWE患者中SUDEP的发病率（1.93/1000人年）高于高收入国家通常报道的发病率，尽管新西兰癫痫患病率存在不确定性。我们怀疑世界范围内猝死的实际发病率比通常报道的要高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsia 医学-临床神经学

CiteScore

10.90

自引率

10.70%

发文量

319

审稿时长

2-4 weeks

期刊介绍： Epilepsia is the leading, authoritative source for innovative clinical and basic science research for all aspects of epilepsy and seizures. In addition, Epilepsia publishes critical reviews, opinion pieces, and guidelines that foster understanding and aim to improve the diagnosis and treatment of people with seizures and epilepsy.