Physical Function Differences by COVID-19 Status: A Cross-Sectional Analysis from the RECOVER Adult Cohort.

IF 3.5 4区医学 Q1 ORTHOPEDICS

Physical Therapy Pub Date : 2025-04-30 DOI:10.1093/ptj/pzaf063

Grace L Kulik Née Ditzenberger, Tianyu Zheng, Sarah E Jolley, Hassan Ashktorab, Hassan Brim, Elen M Feuerriegel, John W Hafner, Rachel Hess, Benjamin D Horne, Mady Hornig, Brandon Johnson, C Kim, Adeyinka O Laiyemo, Grace A McComsey, Janko Ž Nikolich, Kayleigh Reid, John Scherry, Zaki A Sherif, Huong G Tran, Monica Verduzco-Gutierrez, Shelby West, Kristine M Erlandson

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引用次数: 0

Abstract

Importance: Many adults with prior SARS-CoV-2 infection have persistent limitations, but few studies have examined objective physical function impairment that persist longer than 3 months after infection.

Objective: The objective was to characterize physical function impairment among adults with and without SARS-CoV-2 infection.

Design: This study was a retrospective, cross-sectional analysis.

Setting: Researching COVID to Enhance Recovery (RECOVER) initiative, a multi-site observational study in the United States (ClinicalTrials.gov: NCT05172024).

Participants: Participants were adults ≥18 years old with and without SARS-CoV-2 infection.

Exposures: Groups were defined based on COVID-19 status at enrollment: never diagnosed (control), diagnosed with COVID-19 ≤ 12 weeks (recent COVID-19), or > 12 weeks prior to enrollment (remote COVID-19). The RECOVER-Adult Long COVID Index was used to further characterize by Index ≥12 versus 0.

Main outcomes/measures: Physical function (main outcome) was assessed by number of repetitions on a 30-second sit-to-stand test (30STS).

Results: 30STS assessments at enrollment were available from 11,578 participants. 30STS repetitions were lowest in the remote COVID-19 group (n = 4942) with 11.5 (SD = 4.2) repetitions compared to 12.5 (SD = 4.7) repetitions among controls (n = 1887) or 12.2 (SD = 4.5) in recent COVID-19 (n = 4698). Remote COVID-19, but not recent COVID-19, was associated with lower physical function in the adjusted model (-0.61 repetitions; SD = 0.21). Those with RECOVER Long COVID Research Index ≥12 performed 1.6 (SD = 0.2) fewer repetitions than those with an Index equal 0.

Conclusions: Physical function impairment did not show clinically meaningful group differences between RECOVER Adult Cohort participants by COVID-19 status, or by Long COVID Index. Individual responses over time or in response to an intervention may be more clinically relevant.

Relevance: In the RECOVER adult cohort, overall physical function differences by time since COVID-19 or by Long COVID Index were small. Individualized assessments are needed to determine functional impairment following COVID-19 diagnosis and subsequent steps for rehabilitation interventions.

查看原文本刊更多论文

COVID-19状态的身体功能差异：来自康复成人队列的横断面分析

重要性：许多先前感染SARS-CoV-2的成年人存在持续的局限性，但很少有研究检查感染后持续超过3个月的客观身体功能损害。目的：目的是表征有和没有SARS-CoV-2感染的成年人的身体功能障碍。设计：本研究为回顾性横断面分析。环境：研究COVID - 19增强恢复（RECOVER）计划，一项在美国开展的多地点观察性研究（ClinicalTrials.gov: NCT05172024）。参与者：参与者为成年人≥18岁，有无SARS-CoV-2感染。暴露：根据入组时的COVID-19状态定义组：未诊断（对照组），诊断为COVID-19≤12周（近期COVID-19），或入组前12周（远程COVID-19）。恢复-成人长COVID指数（recovery - adult Long COVID Index）以指数≥12对0进一步表征。主要结果/测量：通过30秒坐立测试（30STS）的重复次数来评估身体功能（主要结果）。结果：11,578名参与者入组时进行了30STS评估。远程COVID-19组（n = 4942）的sts重复次数最少，为11.5次（SD = 4.2），而对照组（n = 1887）的sts重复次数为12.5次（SD = 4.7），近期COVID-19组（n = 4698）的sts重复次数为12.2次（SD = 4.5）。在调整后的模型中，远程COVID-19而非近期COVID-19与较低的身体功能相关(-0.61重复；sd = 0.21)。recovery Long COVID研究指数≥12的患者比指数为0的患者重复次数少1.6次（SD = 0.2）。结论：在康复成人队列参与者中，身体功能障碍未显示出有临床意义的组间差异，如COVID-19状态或Long COVID- Index。个体随时间的反应或对干预的反应可能更具临床相关性。相关性：在RECOVER成人队列中，自COVID-19以来按时间或按长COVID指数划分的整体身体功能差异很小。需要进行个性化评估，以确定COVID-19诊断后的功能损害以及随后的康复干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physical Therapy Multiple-

CiteScore

7.10

自引率

0.00%

发文量

187

审稿时长

4-8 weeks

期刊介绍： Physical Therapy (PTJ) engages and inspires an international readership on topics related to physical therapy. As the leading international journal for research in physical therapy and related fields, PTJ publishes innovative and highly relevant content for both clinicians and scientists and uses a variety of interactive approaches to communicate that content, with the expressed purpose of improving patient care. PTJ"s circulation in 2008 is more than 72,000. Its 2007 impact factor was 2.152. The mean time from submission to first decision is 58 days. Time from acceptance to publication online is less than or equal to 3 months and from acceptance to publication in print is less than or equal to 5 months.