Sex differences between mid-life glycaemic traits and brain volume at age 70: a population-based study.

IF 5.3 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

European Journal of Endocrinology Pub Date : 2025-04-30 DOI:10.1093/ejendo/lvaf090

Nasri Fatih, Alun Hughes, Carole H Sudre, Nishi Chaturvedi, Victoria Garfield, Richard J Silverwood, George Ploubidis, Thomas D Parker, Kirsty Lu, David M Cash, Ian B Malone, Andrew Wong, Josephine Barnes, Marcus Richards, Nick C Fox, Jonathan M Schott, Sarah-Naomi James

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Abstract

Higher HbA1c in mid-to-later life has been associated with smaller whole brain volume (WBV) in older women but not men. We explored whether this association was replicated using different markers of (i) glycaemic health [fasting glucose, insulin resistance (HOMA2-IR), and β-cell function (HOMA-%B)] and (ii) brain structure (white or grey matter volume). 453 participants (51% men) from the 1946 British Birth Cohort had glycaemic measures (at age 60-64) and MRI measures (at age ∼70). In women, higher fasting glucose and insulin resistance at age ∼60 were weakly associated with lower WBV at age ∼70 [eg, fasting glucose: β* = -0.07 (95% CI: -0.13, -0.01), P = .02]. No associations emerged for men for any glycaemic marker. HOMA-%B was not associated with brain outcomes in either sex. Women's later-life brain health may be more vulnerable to midlife hyperglycaemia.

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中年血糖特征和70岁时脑容量的性别差异：一项基于人群的研究。

中老年女性较高的HbA1c与较小的全脑容量（WBV）相关，但与男性无关。我们探讨了使用不同的标记物(a)血糖健康(空腹血糖、胰岛素抵抗（HOMA2-IR）和β细胞功能（HOMA-%B）和(B)脑结构（白质或灰质体积）是否可以复制这种关联。来自1946年英国出生队列的453名参与者（51%为男性）进行了血糖测量（60-64岁）和MRI测量（70岁~ 70岁）。在女性中，60 ~ 60岁较高的空腹血糖和胰岛素抵抗与70 ~ 70岁较低的WBV呈弱相关（例如，空腹血糖：β*=-0.07 [95% CI: -0.13, -0.01], p=0.02）。男性与任何血糖指标均无关联。无论男女，HOMA-%B与脑预后无关。女性晚年的大脑健康可能更容易受到中年高血糖的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Endocrinology 医学-内分泌学与代谢

CiteScore

9.80

自引率

3.40%

发文量

354

审稿时长

1 months

期刊介绍： European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.