PET image nonuniformity texture features for metastasis risk prediction in osteosarcoma.

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Muath Almaslamani, Byung-Hyun Byun, Kanghyon Song, Chang-Bae Kong, Sang-Keun Woo
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引用次数: 0

Abstract

Objective: PET image analysis provides tumor heterogeneity data related to neoadjuvant chemotherapy response (NACR) and metastatic risk in osteosarcoma. Ki-67 expression is used to predict metastasis. The accuracy of prediction models with image quantitative features can be improved by including genetic information. Here, we aimed to evaluate the accuracy of a combination of heterogeneous 18F-fluorodeoxyglucose PET image texture features and Ki-67 expression as predictive indicators of metastasis.

Methods: PET images and clinical data of 82 patients with osteosarcoma before and after treatment were collected. Quantitative features were extracted from the PET images obtained before treatment, and the area under the receiver operating characteristic curve (AUC) for NACR and metastatic event was calculated. Relative risk and odds analyses of the quantitative features of the entire image were performed. Kaplan-Meier survival analysis was performed to determine the relationship between image quantitative features and clinical information. The machine learning prediction model was evaluated using valid image quantitative features and various algorithms of the univariate analysis.

Results: Forty-seven image textures were obtained. The AUC values were 0.504-0.62 for NACR and 0.510-0.598 for metastatic events. The NACR and metastatic risk were related to the gray-level run length matrix (GLRLM) run length nonuniformity (RLNU) (relative risk: 1.3846, P = 0.0138 for NACR; relative risk: 2.1284, P = 0.049 for metastatic event) in the univariate analysis. The accuracy of the prediction model using the random forest algorithm with GLRLM RLNU, Ki-67 expression, and NACR was 0.91 for metastatic risk. NACR and metastatic risk were predicted with high accuracy using the nonuniformity in PET image texture.

Conclusion: Combining PET image texture nonuniformity with Ki-67 expression and clinical data can enhance the accuracy of metastasis prediction in osteosarcoma. This multimodal approach may support metastasis risk prediction in osteosarcoma and aid in personalized treatment planning.

PET图像非均匀性纹理特征预测骨肉瘤转移风险。
目的:PET图像分析提供与骨肉瘤新辅助化疗反应(NACR)和转移风险相关的肿瘤异质性数据。Ki-67表达用于预测转移。具有图像定量特征的预测模型可以通过加入遗传信息来提高预测的准确性。在这里,我们旨在评估异质18f -氟脱氧葡萄糖PET图像纹理特征和Ki-67表达组合作为转移预测指标的准确性。方法:收集82例骨肉瘤患者治疗前后的PET图像及临床资料。从治疗前获得的PET图像中提取定量特征,计算NACR和转移事件的接受者工作特征曲线下面积(AUC)。对整个图像的定量特征进行相对风险和几率分析。Kaplan-Meier生存分析确定图像定量特征与临床信息之间的关系。利用有效的图像定量特征和各种单变量分析算法对机器学习预测模型进行评估。结果:获得47种图像纹理。NACR的AUC值为0.504-0.62,转移事件的AUC值为0.510-0.598。NACR和转移风险与灰色跑长矩阵(GLRLM)和跑长不均匀性(RLNU)相关(NACR的相对风险:1.3846,P = 0.0138;相对危险度:2.1284,转移事件P = 0.049)。使用GLRLM、RLNU、Ki-67表达和NACR的随机森林算法预测模型转移风险的准确性为0.91。利用PET图像纹理的不均匀性预测NACR和转移风险具有较高的准确性。结论:结合PET图像纹理不均匀性、Ki-67表达及临床资料可提高骨肉瘤转移预测的准确性。这种多模式方法可能支持骨肉瘤转移风险预测,并有助于个性化治疗计划。
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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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