Cross Talk Between Macrophages and Podocytes in Diabetic Nephropathy: Potential Mechanisms and Novel Therapeutics.

IF 4.4 3区 医学 Q2 CELL BIOLOGY
Mediators of Inflammation Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI:10.1155/mi/8140479
Siming Yu, Zehui Han, Chunsheng Li, Xinxin Lu, Yue Li, Xingxing Yuan, Dandan Guo
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引用次数: 0

Abstract

Diabetic nephropathy (DN) is a leading cause of chronic kidney disease and end-stage renal failure worldwide. Podocytes, essential components of the glomerular filtration barrier (GFB), are profoundly affected in the diabetic milieu, resulting in structural and functional alterations. Concurrently, macrophages, pivotal innate immune cells, infiltrate the diabetic kidney and exhibit diverse activation states influenced by the local environment, playing a crucial role in kidney physiology and pathology. This review synthesizes current insights into how the dynamic cross talk between these two cell types contributes to the progression of DN, exploring the molecular and cellular mechanisms underlying this interaction, with a particular focus on how macrophages influence podocyte survival through various forms of cell death, including apoptosis, pyroptosis, and autophagy. The review also discusses the potential of targeting macrophages to develop more effective treatments for DN.

巨噬细胞和足细胞在糖尿病肾病中的串扰:潜在机制和新的治疗方法。
糖尿病肾病(DN)是慢性肾脏疾病和终末期肾功能衰竭的主要原因。足细胞是肾小球滤过屏障(GFB)的重要组成部分,在糖尿病环境中受到严重影响,导致结构和功能改变。同时,巨噬细胞作为关键的先天免疫细胞,浸润到糖尿病肾脏中,受局部环境影响表现出不同的激活状态,在肾脏生理病理中起着至关重要的作用。这篇综述综合了目前关于这两种细胞类型之间的动态串导如何促进DN进展的见解,探讨了这种相互作用的分子和细胞机制,特别关注巨噬细胞如何通过各种形式的细胞死亡(包括凋亡、焦亡和自噬)影响足细胞存活。本文还讨论了针对巨噬细胞开发更有效的DN治疗方法的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mediators of Inflammation
Mediators of Inflammation 医学-免疫学
CiteScore
8.70
自引率
0.00%
发文量
202
审稿时长
4 months
期刊介绍: Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
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