{"title":"Quality of life after endoscopic vs. conventional open thyroidectomy: a systematic review and meta-analysis.","authors":"Vishesh Agrawal, Sanjay Kumar Yadav, Pawan Agarwal, Dhananjaya Sharma, Saroj Kanta Mishra","doi":"10.1007/s00423-025-03616-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>We have performed a meta-analysis of studies reporting on Health-related quality of life (QoL) after endoscopic thyroidectomy (ETx) vs. open thyroidectomy (OTx).</p><p><strong>Objectives: </strong>The objective was to evaluate the QoL outcomes of ETx compared to OTx.</p><p><strong>Methods: </strong>Eligibility criteria: Studies comparing ETx vs OTx INFORMATION SOURCES: PubMed, EMBASE, the Cochrane library, and online registers were searched for articles comparing QoL in ETx vs OTx.</p><p><strong>Risk of bias: </strong>Articles were assessed for risk of bias using Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool.</p><p><strong>Synthesis of results: </strong>The main summary measures using the random effects model were mean difference (MD).</p><p><strong>Results: </strong>Three studies were included in the meta-analysis. Two studies compared QoL between Transoral Endoscopic Thyroidectomy vs OTx and one compared Transaxillary Endoscopic Thyroidectomy vs OTx. There were no significant differences in the QoL outcomes using SF-36 scale. Pain scores assessed using the visual analogue scale (VAS) and overall satisfaction were also comparable between ETx and OTx.</p><p><strong>Conclusion: </strong>Our systematic review and meta-analysis indicate that QoL outcomes for ETx and OTx may be comparable based on the currently available evidence. The substantial heterogeneity across studies and the lack of adequately powered trials limit the generalizability of these findings. Future large-scale randomized controlled trials with robust QoL measures, such as ThyPRO-39, are needed to provide higher-quality evidence on the comparative effectiveness of ETx versus OTx.</p>","PeriodicalId":17983,"journal":{"name":"Langenbeck's Archives of Surgery","volume":"410 1","pages":"144"},"PeriodicalIF":2.1000,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021691/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Langenbeck's Archives of Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00423-025-03616-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
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Abstract
Background: We have performed a meta-analysis of studies reporting on Health-related quality of life (QoL) after endoscopic thyroidectomy (ETx) vs. open thyroidectomy (OTx).
Objectives: The objective was to evaluate the QoL outcomes of ETx compared to OTx.
Methods: Eligibility criteria: Studies comparing ETx vs OTx INFORMATION SOURCES: PubMed, EMBASE, the Cochrane library, and online registers were searched for articles comparing QoL in ETx vs OTx.
Risk of bias: Articles were assessed for risk of bias using Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool.
Synthesis of results: The main summary measures using the random effects model were mean difference (MD).
Results: Three studies were included in the meta-analysis. Two studies compared QoL between Transoral Endoscopic Thyroidectomy vs OTx and one compared Transaxillary Endoscopic Thyroidectomy vs OTx. There were no significant differences in the QoL outcomes using SF-36 scale. Pain scores assessed using the visual analogue scale (VAS) and overall satisfaction were also comparable between ETx and OTx.
Conclusion: Our systematic review and meta-analysis indicate that QoL outcomes for ETx and OTx may be comparable based on the currently available evidence. The substantial heterogeneity across studies and the lack of adequately powered trials limit the generalizability of these findings. Future large-scale randomized controlled trials with robust QoL measures, such as ThyPRO-39, are needed to provide higher-quality evidence on the comparative effectiveness of ETx versus OTx.
期刊介绍：
Langenbeck''s Archives of Surgery aims to publish the best results in the field of clinical surgery and basic surgical research. The main focus is on providing the highest level of clinical research and clinically relevant basic research. The journal, published exclusively in English, will provide an international discussion forum for the controlled results of clinical surgery. The majority of published contributions will be original articles reporting on clinical data from general and visceral surgery, while endocrine surgery will also be covered. Papers on basic surgical principles from the fields of traumatology, vascular and thoracic surgery are also welcome. Evidence-based medicine is an important criterion for the acceptance of papers.
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