The co-occurrence of IgG4-related disease and malignancy: insights from a prospective cohort study.

IF 3.4 4区医学 Q2 RHEUMATOLOGY

Clinical and experimental rheumatology Pub Date : 2025-04-09 DOI:10.55563/clinexprheumatol/5c7nti

Yufei Guo, Yiwen Wang, Minhui Lu, Hui Wang, Chao Xue, Xi Zheng, Wenrui Zhang, Yurong Zhao, Jie Zhang, Kunpeng Li, Jianglin Zhang, Feng Huang, Jian Zhu

{"title":"The co-occurrence of IgG4-related disease and malignancy: insights from a prospective cohort study.","authors":"Yufei Guo, Yiwen Wang, Minhui Lu, Hui Wang, Chao Xue, Xi Zheng, Wenrui Zhang, Yurong Zhao, Jie Zhang, Kunpeng Li, Jianglin Zhang, Feng Huang, Jian Zhu","doi":"10.55563/clinexprheumatol/5c7nti","DOIUrl":null,"url":null,"abstract":"Objectives: This study investigates the relationship between IgG4-related disease (IgG4-RD) and malignancies, focusing on tumour distribution and risk factors for malignancy development during follow-up.Methods: We analysed a prospective cohort of 278 IgG4-RD patients, including 22 with malignancies, and calculated standardised incidence ratios (SIRs). Bayesian statistical models were employed to identify risk factors.Results: Among 278 IgG4-RD patients, 22 (7.9%) developed malignancies. Lung cancer (13.6%) was the most prevalent malignancy, with a significantly higher incidence in the follow-up group compared to the history/concurrent group (19.3% vs. 7.0%; p=0.008). Testicular cancer occurred exclusively in the history/concurrent group (3.5%) and was absent in the follow-up group (p=0.044). The overall SIR was 3.28 (95% CI: 1.31-5.58) and lymphoma exhibited a markedly high SIR of 17.63 (95% CI: 0-52.89). Elevated ESR (estimate: 0.12, 95% CI: 0.04-0.23) and more organ involvements (estimate: 1.94, 95% CI: 0.31-3.93) were identified as significant risk factors for malignancy development.Conclusions: IgG4-RD patients exhibit an elevated risk of specific malignancies, particularly lymphoma, with elevated ESR and greater organ involvement identified as significant risk factors for malignancy development during follow-up period.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and experimental rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.55563/clinexprheumatol/5c7nti","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: This study investigates the relationship between IgG4-related disease (IgG4-RD) and malignancies, focusing on tumour distribution and risk factors for malignancy development during follow-up.

Methods: We analysed a prospective cohort of 278 IgG4-RD patients, including 22 with malignancies, and calculated standardised incidence ratios (SIRs). Bayesian statistical models were employed to identify risk factors.

Results: Among 278 IgG4-RD patients, 22 (7.9%) developed malignancies. Lung cancer (13.6%) was the most prevalent malignancy, with a significantly higher incidence in the follow-up group compared to the history/concurrent group (19.3% vs. 7.0%; p=0.008). Testicular cancer occurred exclusively in the history/concurrent group (3.5%) and was absent in the follow-up group (p=0.044). The overall SIR was 3.28 (95% CI: 1.31-5.58) and lymphoma exhibited a markedly high SIR of 17.63 (95% CI: 0-52.89). Elevated ESR (estimate: 0.12, 95% CI: 0.04-0.23) and more organ involvements (estimate: 1.94, 95% CI: 0.31-3.93) were identified as significant risk factors for malignancy development.

Conclusions: IgG4-RD patients exhibit an elevated risk of specific malignancies, particularly lymphoma, with elevated ESR and greater organ involvement identified as significant risk factors for malignancy development during follow-up period.

查看原文本刊更多论文

igg4相关疾病和恶性肿瘤的共同发生：来自一项前瞻性队列研究的见解

目的：本研究探讨igg4相关疾病（IgG4-RD）与恶性肿瘤的关系，重点关注随访期间肿瘤分布和恶性发展的危险因素。方法：我们分析了278例IgG4-RD患者的前瞻性队列，其中包括22例恶性肿瘤，并计算了标准化发病率（SIRs）。采用贝叶斯统计模型识别危险因素。结果：278例IgG4-RD患者中，22例（7.9%）发生恶性肿瘤。肺癌（13.6%）是最常见的恶性肿瘤，随访组的发病率明显高于病史/并发组(19.3% vs. 7.0%；p = 0.008)。睾丸癌仅在病史/并发组发生（3.5%），在随访组无发生（p=0.044）。总体SIR为3.28 (95% CI: 1.31-5.58)，淋巴瘤SIR明显高，为17.63 （95% CI: 0-52.89）。ESR升高（估计：0.12,95% CI: 0.04-0.23）和更多器官受累（估计：1.94,95% CI: 0.31-3.93）被认为是恶性肿瘤发展的重要危险因素。结论：IgG4-RD患者表现出特定恶性肿瘤的高风险，特别是淋巴瘤，在随访期间，ESR升高和更大的器官受累被确定为恶性肿瘤发展的重要危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical and experimental rheumatology 医学-风湿病学

CiteScore

6.10

自引率

18.90%

发文量

377

审稿时长

3-6 weeks

期刊介绍： Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.