A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment.

IF 5.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Medicine Pub Date : 2025-04-09 DOI:10.1186/s13020-025-01096-z

Danushiya Ehambarampillai, Murphy Lam Yim Wan

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引用次数: 0

Abstract

Lignans derived from Schisandra chinensis have attracted significant attention for their diverse pharmacological activities and clinical potential. This review presents a comprehensive analysis of the pharmacological properties of Schisandra chinensis lignans, including their antioxidant, anti-inflammatory, neuroprotective, hepatoprotective, antibacterial/viral, antidiabetic and anticancer effects. Their multifaceted mechanisms of action hold promise for therapeutic areas such as cancer, neurodegenerative diseases and metabolic disorders, aligning with urgent clinical needs. Additionally, this review explores the pharmacokinetics of these bioactive compounds, highlighting challenges in their absorption, distribution, metabolism and excretion, which impact their bioavailability. Recent advancements in drug delivery systems are discussed, highlighting their potential to enhance therapeutic efficacy in clinical settings. Furthermore, the synergistic effects of combining these lignans with other therapeutic agents are considered a strategy to increase their efficacy. Future research is imperative to identify additional active components and elucidate novel mechanisms of action, paving the way for expanded therapeutic applications and unlocking the full clinical potential of Schisandra chinensis in disease prevention and treatment.

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综述了五味子木脂素的药代动力学、药理机制及其在疾病防治中的应用前景。

五味子木脂素因其丰富的药理活性和临床应用潜力而备受关注。本文综述了五味子木脂素的药理作用，包括抗氧化、抗炎、神经保护、肝保护、抗菌/病毒、抗糖尿病和抗癌作用。其多方面的作用机制为癌症、神经退行性疾病和代谢紊乱等治疗领域带来了希望，符合迫切的临床需求。此外，本文还探讨了这些生物活性化合物的药代动力学，强调了它们在吸收、分布、代谢和排泄方面的挑战，这些挑战会影响它们的生物利用度。讨论了药物输送系统的最新进展，强调了它们在临床环境中提高治疗效果的潜力。此外，将这些木脂素与其他治疗剂结合的协同效应被认为是提高其疗效的一种策略。未来的研究需要确定更多的有效成分，阐明新的作用机制，为扩大治疗应用铺平道路，释放五味子在疾病预防和治疗方面的全部临床潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.90

自引率

4.10%

发文量

133

审稿时长

31 weeks

期刊介绍： Chinese Medicine is an open access, online journal publishing evidence-based, scientifically justified, and ethical research into all aspects of Chinese medicine. Areas of interest include recent advances in herbal medicine, clinical nutrition, clinical diagnosis, acupuncture, pharmaceutics, biomedical sciences, epidemiology, education, informatics, sociology, and psychology that are relevant and significant to Chinese medicine. Examples of research approaches include biomedical experimentation, high-throughput technology, clinical trials, systematic reviews, meta-analysis, sampled surveys, simulation, data curation, statistics, omics, translational medicine, and integrative methodologies. Chinese Medicine is a credible channel to communicate unbiased scientific data, information, and knowledge in Chinese medicine among researchers, clinicians, academics, and students in Chinese medicine and other scientific disciplines of medicine.